Evaluation of High-Frequency Oscillations Detected by a Novel Signal Analysis Algorithm on Scalp Electroencephalography for Differentiating Patients With Epilepsy From Healthy Controls
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Mean residence time of high-frequency oscillation activity in the ripple band (80-250 Hz) on scalp EEG
研究概览
简要总结
This observational case-control study aims to evaluate whether high-frequency oscillations (HFOs) detected on scalp electroencephalography (EEG) can differentiate patients with epilepsy from healthy controls. A signal-processing algorithm was developed to identify HFO activity in scalp EEG recordings, with particular focus on ripple (80-250 Hz) and fast ripple (250-500 Hz) frequency bands. Scalp EEG recordings obtained from patients with epilepsy and healthy controls are analyzed after preprocessing and filtering steps. The main outcome is the mean residence time of HFO-related activity above a predefined threshold in the ripple and fast ripple bands. The study investigates whether this noninvasive EEG-based approach may provide a useful biomarker for epilepsy diagnosis.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Inclusion Criteria for Epilepsy Group
- •Adults diagnosed with epilepsy
- •Availability of routine awake scalp EEG recording suitable for analysis
- •EEG recorded with the study protocol and technical specifications
- •Inclusion Criteria for Control Group
- •Adults without epilepsy
- •Referred for EEG evaluation in the context of syncope differential diagnosis
- •Scalp EEG recording suitable for analysis
排除标准
- •EEG recordings with inadequate technical quality or excessive artifact burden preventing HFO analysis
- •Individuals not meeting study group definitions
研究组 & 干预措施
normal control
non epileptic patients with eeg
epilepsy patients
epileptic patients with eeg
结局指标
主要结局
Mean residence time of high-frequency oscillation activity in the ripple band (80-250 Hz) on scalp EEG
时间窗: At the time of EEG assessment / baseline
The mean duration for which the ripple-band signal envelope remains above the predefined threshold, compared between epilepsy and control groups.
次要结局
未报告次要终点