Pulse EnRiched Food and Exercise Clinical Trials (PERFECT Project): Part 1 - Acute Effects of Pulse Ingredients in Snack Products on Appetite, Blood Glucose, and Food Intake in Adults - Study 3
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 2
- 主要终点
- Plasma Glucose and Insulin Concentrations
研究概览
简要总结
The objectives are to test the acute effects of different bagels containing pulse ingredients on: 1) post-prandial blood glucose, insulin and appetite for two hours, and 2) food intake two hours following consumption of pulse products.
The investigators hypothesize that bagels containing pulse ingredients will lead to lower blood glucose, insulin, appetite and food intake responses compared to non-pulse bagels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Normoglycemic (<5.6 mmol/L) and normotensive (systolic blood pressure <140 mm Hg and diastolic blood pressure below < 90 mm Hg)
- •BMI of 18.5-29.9 kg/m2
排除标准
- •Restrained eaters
- •Regularly skip breakfast
- •Those who are active (organized activities or athletic training at a high intensity; ≥ 150 min per week of moderate to vigorous physical activity)
- •Those on medications that may influence study outcomes or have experienced any gastrointestinal related health conditions/surgeries over the past year.
- •Those unable to walk for an hour continuously
结局指标
主要结局
Plasma Glucose and Insulin Concentrations
时间窗: 0-200
Measured in blood using intravenous catheter at 12 time points used to calculate area under curve (AUC). Glucose will be determined by automated methods using Abbot Spectrum CCX Analyzer, and Insulin will be measured by commercially available RIA kits
Food Intake
时间窗: at 120 min
Ad-libitum meal. Food consumed measured by weight
Subjective Appetite
时间窗: 0-200 min
Motivation-to-eat VAS questionnaire used to calculate area under curve (AUC)
次要结局
- Palatability of meal(at 140 mins)
- Physical comfort(0 - 200 min)
- Energy/fatigue measured by VAS questionnaire(0 - 200 mins)
- Palatability of treatments(at 5 mins)