Dynamic Motor Cortical Responses to Subdural Electrical Stimulation.
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 入组人数
- 50
- 主要终点
- Number of arm movements in 60 seconds
研究概览
简要总结
The purpose of this study is to better understand how subdural electrical stimulation of the brain affects motor cortical oscillations
详细描述
Direct cortical stimulation (DCS) has shown the potential to improve symptoms in patients with Parkinson's disease, however its effects have not been consistent in randomized studies to date, limiting widespread adoption of this technology. A critical gap in our knowledge is a detailed understanding of how DCS affects motor areas in the brain. Investigators propose using subdural DCS (sDCS) while simultaneously recording directly from motor cortex using subdural electrocorticography (sECoG) in patients undergoing deep brain stimulation surgery. Investigators expect this novel approach to broaden our understanding of sDCS application and possibly lead to therapeutic advances in this population.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Device Feasibility
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with PD and consented and scheduled for DBS surgery with the PI
- •Age 18-80
排除标准
- •Patients unable to actively participate in the consent process physically and/or cognitively
- •Previous adverse reaction to Keppra (levetiracetam)
- •Prior intracranial surgery with the exception of deep brain stimulation surgery
- •Prior brain radiotherapy
- •Prior history of intracranial tumor, intracranial infection or cerebrovascular malformation
- •Prior history of seizures
结局指标
主要结局
Number of arm movements in 60 seconds
时间窗: 60 seconds
Number of arm movements in 60 seconds
次要结局
未报告次要终点