Impact of Acute Exercise on Brain Insulin Sensitivity in Middle-aged to Older Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 16
- 试验地点
- 8
- 主要终点
- Brain insulin sensitivity
研究概览
简要总结
Dementia is a leading cause of death in the United States among aging adults. Brain insulin resistance has emerged as a pathologic factor affecting memory, executive function as well as systemic glucose control. Regular aerobic exercise decreases Alzheimer's Disease (AD) risk, in part, through changes in brain structure and function. However, there is limited data available on how exercise impacts brain insulin resistance in aging. This study will test the effect of acute exercise on brain insulin sensitivity in middle-aged to older adults. The study will also examine cognition and cardiometabolic health in relation to brain insulin sensitivity.
详细描述
Obesity, hypertension, high blood glucose (e.g. prediabetes/type 2 diabetes), and physical inactivity is thought to worsen brain insulin resistance and reduce cerebral blood flow. This suggests lifestyle approaches may be necessary to counteract declines in brain health. Regular aerobic exercise decreases Alzheimer's Disease (AD) risk, in part, through changes in brain structure and function. Moreover, exercise-related structural changes in the brain, namely increased hippocampal volume, is linked to improved memory. However, there is limited data available on how exercise impacts brain insulin resistance in aging. It is also unclear if one bout of exercise may help improve brain insulin responses to insulin before fitness gains or weight loss in people at risk for dementia, type 2 diabetes and cardiovascular disease. Because single bouts of exercise are established to improve metabolic and vascular insulin sensitivity in people with obesity, the investigators anticipate exercise to raise brain insulin sensitivity in relation to cognition and cardiometabolic health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Male or female >/=40 and </=80 years old.
- •Has a body mass index >/=25 and </=45 kg/m
- •Physical Activity (<150 min of moderate/high intensity exercise per week)
排除标准
- •Subjects who have not been weight stable (>2 kg weight change in past 3 months)
- •Subjects who are smokers or who have quit smoking <1 years ago
- •Subjects with abnormal estimated glomerular filtration rate (eGFR).
- •Hypertriglyceridemic (>400 mg/dl) and hypercholesterolemic (>260 mg/dl) subjects
- •Hypertensive (>160/100 mmHg)
- •Subjects with a history of significant metabolic, cardiac, congestive heart failure, cerebrovascular, hematological, pulmonary, gastrointestinal, liver, renal, or endocrine disease or cancer that in the investigator's opinion would interfere with or alter the outcome measures or impact subject safety.
- •Pregnant (as evidenced by positive urine pregnancy test) or nursing women
- •Subjects with contraindications to participation in an exercise
- •Current Pregnancy
- •Currently taking active weight suppression medication (e.g. phentermine, orlistat, lorcaserin, naltrexone-bupropion in combination, liraglutide, benzphetamine, diethylpropion, phendimetrazine)
- •Subjects currently taking medications that affect heart rate and rhythm (i.e. Ca++ channel blockers, nitrates, alpha- or beta-blockers).
- •Known contraindications for MRI imaging
结局指标
主要结局
Brain insulin sensitivity
时间窗: Change from baseline to exercise; about 1 week apart
MRI arterial spin labeling, cerebral blood flow
次要结局
- Blood Free Fatty Acids(Change from baseline to exercise; about 1 week apart)
- Carbohydrate Use(Change from baseline to exercise; about 1 week apart)
- Blood Glucose(Change from baseline to exercise; about 1 week apart)
- Cognition(Change from baseline to exercise; about 1 week apart)
- Systolic and Diastolic Blood Pressure(Change from baseline to exercise; about 1 week apart)
研究者
Steven K Malin, PhD
Associate Professor
Rutgers, The State University of New Jersey