Mannitol to prevent an exacerbation of Complex Regional Pain Syndrome (CRPS) after hand surgery

niversity Medical Centre Utrecht (UMCU) (Netherlands)0 个研究点目标入组 50 人开始时间: 2006年1月27日最近更新: 2015年1月13日

试验速览

暂无简介。

•1. Age at least 18 years
•2. History of CRPS, indicated by the presence of the following characteristics during the past 3 years (adapted CRPS I criteria according to Bruehl):
•2.1. Continuing pain, disproportionate to any inciting event
•2.2. At least 1 symptom in one of the following 4 categories:
•2.2.1. Sensory: hyperalgesia
•2.2.2. Vasomotor: temperature asymmetry or skin color changes or skin color asymmetry
•2.2.3. Sudomotor/edema: edema or sweating changes or sweating asymmetry
•2.2.4. Motor/trophic: diminished range of motion or motor dysfunction or trophic changes
•3. The presence of CRPS signs is not mandatory
•4. Surgery on the affected upper extremity (a.o. carpal-tunnel syndrome, joint surgery on wrist and fingers)

•1. Allergy to mannitol
•2. Allergy to hydrochlorothiazide
•3. Clinically relevant renal impairment (creatinine =150% normal)
•4. History of cardiac failure (orthopnea, edema, exertional dyspnea, admissions for cardiac failure)
•5. CRPS in both upper extremities
•6. Other pain syndromes affecting functional testing or pain scores
•7. Infection
•8. Pregnancy
•9. No informed consent

发起方

niversity Medical Centre Utrecht (UMCU) (Netherlands)