NCT05775263尚未招募不适用
Validation of UK Protocols to Exclude Brain Blood Flow During Normothermic Regional Perfusion (NRP)
适应症
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 10
- 主要终点
- CT angiogram
研究概览
简要总结
This study aims to evaluate both Abdominal Normothermic Regional Perfusion (A-NRP) and Thoracoabdominal-NRP (TA-NRP) techniques, proving that brain blood flow is not resumed during NRP. This will be assessed through the use of two modalities: CT angiogram of the brain and continuous Hb02 readings. The study group hypothesise that such assessment methods will provide evidence to indicate that brain blood flow is not present during NRP and promote trust in the use of such novel techniques in routine practice.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DCD donors in Cambridge University Hospital
- •Planned A-NRP
- •Consent for study has been obtained
- •Those who meet the appropriate criteria for DCD donation following WOLST
- •≥ 18 years of age
- •≤ 75 years of age
排除标准
- •DBD organ donors
- •DCD organ donations outside of Cambridge University Hospital
- •DCD donors without planned A-NRP
- •DCD donors whose family have withheld consent for brain blood flow investigations.
- •Patients who do not meet the appropriate criteria for DCD donation following WOLST
- •Patients with injuries that will physically prevent use of the necessary assessment methods
结局指标
主要结局
CT angiogram
时间窗: 30 minutes from establishment of NRP
Brain blood flow
次要结局
- Cerebral oximetry(Prior to withdrawal of life sustaining treatment to 30 minutes after establishment of NRP)
研究者
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