Interest of ST2 to Diagnosis and Management of Patients With Heart Failure (HF)
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 123
- 试验地点
- 2
- 主要终点
- Rehospitalization
研究概览
简要总结
Heart failure (HF) is a severe disease, burdened with a poor prognosis (30% mortality at 2 years, 30% of rehospitalization within 1 month). It is also a major cause of health burden representing between 1.5 and 2 billions euros per year in France. Approximately 75% of these costs are due to hospitalization.
Besides physical examination and echocardiography, biology may help refine the diagnosis, but also could provide powerful prognostic parameters.
This study aims to assess the value of ST2 in the management of patients admitted for HF to reduce readmission at one month.
详细描述
Background and rationale:
Heart failure (HF) is a severe disease, burdened with a poor prognosis (30% mortality at 2 years, 30% of rehospitalization within 1 month). It is also a major cause of health burden representing between 1.5 and 2 billions euros per year in France. Approximately 75% of these costs are due to hospitalization.
Besides physical examination and echocardiography, biology may help refine the diagnosis, but also could provide powerful prognostic parameters. The natriuretic peptides are already available and widely used to this purpose. Other biomarkers such as fibrosis markers are promising. In a recently published preliminary work of a cohort of 180 cardiac patients, ST2 is proving to be a powerful prognostic biomarker.
This study aims to assess the value of ST2 in the management of patients admitted for HF to reduce readmission at one month.
Primary and secondary endpoints:
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Heart failure hospitalization
排除标准
- •Other study
- •Pregnancy, feeding
- •Not possible to perform information
研究组 & 干预措施
ST2-guided strategy
Management of patients follow the international guidelines but are also guided by the ST2, to adapt the drugs indicated in patients with HF.
干预措施: ST2-guided strategy (Other)
Conventional strategy
Conventional strategy to manage the patients with HF, following the international guidelines
干预措施: Conventional strategy (Other)
结局指标
主要结局
Rehospitalization
时间窗: 1 month
The frequence of the rehospitalization of the patient according to the treatment received
次要结局
- Rehospitalization for heart failure(1 month and 1 year)
- Biological markers of HF Assay(1 month and 1 year)
- Mortality(1 month and 1 year)
- Stay at hospital duration(1 month and 1 year)
- Markers of the renal function assay(1 month and 1 year)
- Economic evaluation(1 month and 1 year)
- Rehospitalization for all causes(1 month and 1 year)