NCT02724241已完成不适用
The Effects of Electronic Cigarettes on Sympathetic Nerve Activity and Oxidative Stress
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 2
- 主要终点
- Paraoxonase
研究概览
简要总结
Randomized controlled trial of electronic cigarettes with nicotine, without nicotine, and sham control, on sympathetic nerve activity and markers of oxidative stress.
详细描述
Participants will use an electronic cigarette on 3 occasions: 1) with nicotine, 2) without nicotine, 3) sham control, and measures of autonomic tone, including heart rate variability (HRV) and sympathetic nerve activity (MSNA: microneurography), and oxidative stress will be measured pre and post exposure.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Cardiac disease
- •Respiratory disease
- •Diabetes mellitus
结局指标
主要结局
Paraoxonase
时间窗: less than 1 hour after exposure
plasma oxidative stress
Heart Rate variability
时间窗: 10 minutes after exposure
Heart rate variability is a measure of autonomic tone
次要结局
- muscle sympathetic nerve activity(10 minutes after exposure)
研究者
Holly R Middlekauff
Professor of Medicine
University of California, Los Angeles
研究点 (2)
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