The Effectiveness of Oral Antiseptics on the Intraoral Viral Load of SARS-CoV-2
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- RT-PCR analysis
研究概览
简要总结
In a study conducted on 75 COVID-19 patients, the effect of SARS-CoV-2 on viral load was investigated as a result of the use of hypochlorous acid and povidone-iodine as an oral antiseptic.
详细描述
Before and 30 minutes after rinsing with mouth antiseptics, the participants were asked to rinse the mouth and throat for 30 seconds with 0.9% isotonic saline. The sample was sputtered into a sterile plastic container. The participants were grouped according to the type of oral antiseptics used. The effectiveness of SARS-CoV-2 viral load was investigated by rinsing the mouth and throat for 30 seconds with 20 ml of hypochlorous acid, povidone-iodine, and isotonic saline. Viral load was analyzed by RT-PCR analysis. The results were evaluated by statistical analysis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Positive SARS-CoV-2 RT-PCR result,
- •Adult hospitalized patient,
- •The participants have the physical and psychological ability to follow the instructions in the study.
排除标准
- •Patients intubated and supported by a mechanical respirator,
- •Severe acute or chronic medical or psychiatric condition,
- •History of significant adverse effects following use of oral hygiene products such as toothpaste and mouth rinses,
- •Active uncontrolled thyroid disease,
- •Developmental/cognitive disability,
- •Pregnancy,
- •Undergoing radioactive iodine therapy.
研究组 & 干预措施
Hypochlorous acid group
The effect of 0.02% Hypochlorous acid solution on viral load was investigated by using 25 COVID-19 patients as an oral antiseptic for 30 seconds.
干预措施: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO) (Drug)
Povidone-iodine group
The effect on viral load was investigated by using 0.5% Povidone-iodine solution as an oral antiseptic for 30 seconds in 25 COVID-19 patients.
干预措施: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO) (Drug)
Saline group
The effect on viral load was investigated by using 0.9% isotonic saline solution as a placebo for 30 seconds in 25 COVID-19 patients.
干预措施: Hypochlorous Acid 0.02% Soln,Top (Crystaline) (HClO) (Drug)
结局指标
主要结局
RT-PCR analysis
时间窗: two weeks
For the quantitative analysis of the amount of SARS-CoV-2 RNA in the obtained samples, the Real-time Reverse Transcyptase Polymerase Chain Reaction method was used.
次要结局
未报告次要终点
研究者
Sema Nur Sevinc
Assistant Professor
Ataturk University