Predicting 28-Day mortality in adult patients with sepsis or septic shock using combination of point of care tests including Procalcitonin, Lactate, NT-proBNP, and Diastolic dysfunction: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 144
- 试验地点
- 1
- 主要终点
- Predicting the outcome (28-day mortality) using combined score of procalcitonin, lactate, NT-pro BNP, and E/e’ in patients with sepsis and septic shock
研究概览
简要总结
Several point of care biomarkers such asprocalcitonin, NT pro BNP, lactate etc. have been independently assessed fortheir association with outcome in sepsis. Also Diastolic dysfunction was found to beindependently, a major predictor of mortality in sepsis.
Therefore, we are planning a study topredict the short term (28 days) mortality in adult patients with sepsis orseptic shock using the combination of easily available point of care tests i.e procalcitonin, lactate, NT-pro BNP, and diastolicdysfunction assessed by transthoracic 2D-Echo.
We hypothesized thata combination of point of care test biomarkers and diastolic dysfunction usingE/e’ ratio could predict 28- day mortality in adultpatients with sepsis or septic shock with high sensitivity and specificity
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 75.00 Year(s)（—）
- 性别
- All
入选标准
- •Diagnosis of Sepsis or septic shock (Sepsis -3 definition) in patients who are >18 years of age admitted to AICU.
排除标准
- •1.Patient refusal.
- •2.Pregnant patients.
- •3.Pre-existing impaired left ventricular function, myocardial infarction, valvular heart disease, cardiac arrythmias.
- •4.Traumatic brain injury.
- •5.Terminal stage of disease (Malignancy, Chronic Renal Failure, End stage liver disease).
- •6.Poor Echo window.
结局指标
主要结局
Predicting the outcome (28-day mortality) using combined score of procalcitonin, lactate, NT-pro BNP, and E/e’ in patients with sepsis and septic shock
时间窗: biomarker measurement at admission
次要结局
- Comparing the ability of outcome prediction (28-day mortality) of each of four variable V/s SOFA score.
- Comparing combined score V/s SOFA score for outcome prediction (28-day mortality).