NCT01022684已完成不适用
Correlation of Inflammatory Markers Such as LpPLA2,MCP-1 and hsCRP for Predicting Vascular Inflammation; Analysis With 18F-Fluorodeoxyglucose Positron Emission Tomography
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 150
- 试验地点
- 1
- 主要终点
- Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET
研究概览
简要总结
Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. Various inflammatory markers such as LpPLA2,MCP-2 and hsCRP are well-known prognostic factors for the cardiovascular event.
18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.Therefore, the purpose of the study is to demonstrate the correlation between various inflammatory markers and vascular inflammation detected by 18FDG-PET.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 20 Years 至 88 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy patients for visiting routine medical check in our clinic
排除标准
- •History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
- •Stage 2 hypertension (resting blood pressure, ≥160/100 mmHg)
- •Malignancy
- •Severe renal or hepatic disease
- •Subjects taking medications that might affect inflammation such as NSIAD and statin
结局指标
主要结局
Correlation between various inflammatory markers including LpPLA2,MCP-1 and hsCRP and vascular inflammation analyzed by 18FDG-PET
时间窗: 12 weeks
次要结局
- Correlation between various inflammatory markers and atherosclerosis measured by carotid intima media thickness(12 weeks)
研究者
研究点 (1)
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