Impact of Parathyroidectomy on Vascular Calcification and Clinical Outcome in Hemodialysis Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- emergent adverse postoperative events and assessment of the degree of vascular calcification
研究概览
简要总结
The aim of this study is to assess the clinical, laboratory and vascular calcification outcome within 6 months duration in patients undergoing surgical parathyroidectomy (total, subtotal, and total with autotransplantation)
详细描述
All patients above the age of 18, with end stage renal disease maintained on regular hemodialysis and are indicated for surgical parathyroidectomy.
The indications for parathyroidectomy included persistently elevated intact parathormone hormone levels of greater than 500 pg/mL, uncontrolled hypercalcaemia with hyperphosphataemia or clinical symptoms of secondary hyperparathyroidism refractory to medical treatment. These symptoms included bone pain, pruritus, fracture, fatigue and calciphylaxis
These patients will be exposed to pre-operative evaluation of clinical, laboratory and vascular calcification in abdominal aorta and coronary calcium scoring using ECG- gated non contrast CT in hemodialysis patients undergoing parathyroidectomy
Post-operative evaluation of clinical, laboratory and vascular calcification in abdominal aorta and coronary calcium scoring using non contrast CT will be done 6 months post-operative
Assessment of the relation between preoperative and postoperative measures
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •All patients above the age of 18
- •patients with End stage renal disease maintained on regular hemodialysis
- •indicated for surgical parathyroidectomy
排除标准
- •Chronic kidney disease patients not yet on regular Hemodialysis
- •patients who had primary hyperparathyroidism
- •patients who had received kidney transplantation
- •patients who underwent repeated parathyroidectomy
- •patients who were lost to follow-up or with missing data.
结局指标
主要结局
emergent adverse postoperative events and assessment of the degree of vascular calcification
时间窗: 6 months
assessment of emergent adverse postoperative events as bleeding, indication for mechanical ventilation and intensive care unit admission, vocal cord injury and development of hypoparathyroidism with persistent hypocalcemia assessment of degree of vascular calcification via measuring calcium scoring through ECG gated non contrast CT
次要结局
- Emergent Adverse events on clinical status of the patient(6 months)
- Emergent Adverse events on laboratory parameters(6 months)
- Emergent Adverse events on Quality of life through assessing physical functioning, limitations due to physical health, limitations due to emotional problems, Energy/Fatigue, Emotional wellbeing, Social functioning, Pain, and General health(6 months)
研究者
Nadia Mohsen Abdu Ibrahim
consultant of nephrology
Mansoura General Hospital