Continuous positive airway pressure therapy withdrawal - a model to evaluate treatment modalities for sleep apnoea: a randomised controlled trial

niversity Hospital of Zurich (Switzerland)0 个研究点目标入组 40 人开始时间: 2009年7月14日最近更新: 2015年1月13日

适应症

试验速览

暂无简介。

•1. Objectively confirmed obstructive sleep apnoea with an original oxygen desaturation index (ODI) (greater than or equal to 4% dips) of between 10 and 50/h
•2. Currently greater than 10 oxygen desaturations (greater than or equal to 4% dips) during an ambulatory nocturnal pulse oximetry performed at the end of a 4-night period without CPAP
•3. Treated with CPAP for more than 12 months, minimal compliance 4 hours per night
•4. Written informed consent
•5. Aged 20 - 75 years (inclusive), either sex

•1. Previous ventilatory failure (awake resting arterial oxygen saturation less than 93% or arterial partial pressure of carbon dioxide [PCO2] greater than 6 kPa)
•2. Unstable, untreated coronary or peripheral artery disease, severe arterial hypertension (greater than 180/110 mmHg)
•3. Previously diagnosed with Cheyne-Stokes breathing
•4. Current professional driver
•5. Any sleep related accident
•6. Aged less than 20 or greater than 75 years at trial entry
•7. Mental or physical disability precluding informed consent or compliance with the protocol
•8. Non-feasible trial follow-up (for example, distance from follow-up centre, physical inability)

发起方

niversity Hospital of Zurich (Switzerland)