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临床试验/NCT05608161
NCT05608161尚未招募不适用

Correlation Between Peripheral Hearing Loss and Auditory Perception Impairment in Patients With Unilateral Sudden Deafness and Its Underlying Neural Mechanism

Peking University People's Hospital0 个研究点目标入组 10 人开始时间: 2022年11月10日最近更新:
适应症

试验速览

阶段
不适用
状态
尚未招募
入组人数
10
主要终点
Change from Baseline Noisy speech recognition rate

研究概览

简要总结

At present, few research on the auditory perception function and possible neural mechanisms of unilateral sudden hearing loss patients with complete or partial recovery of peripheral hearing.This project evaluate the speech perception function in noise of unilateral sudden hearing loss patients with with complete and partial hearing recovery by cognitive behavioral experiments, event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI), and longitudinal follow-up to explore its underlying neural mechanisms.

详细描述

In clinical practice, many unilateral sudden hearing loss patients with complete and partial recovery of peripheral hearing still complain of hearing discomfort, especially difficulty in speech recognition in noisy environments. At present, there is still a lack of research on the auditory perception function and possible neural mechanisms of unilateral sudden hearing loss patients with complete or partial recovery of peripheral hearing. From the perspective of cognitive psychology, this project uses cognitive behavioral experiments, event-related potentials (ERPs) and functional magnetic resonance imaging (fMRI) to evaluate the reverberation environment of unilateral sudden hearing loss patients with complete and partial hearing recovery, and longitudinal follow-up to explore its underlying neural mechanisms. The investigators hope to understand the possible difficulties of binaural processing and auditory perception in patients with unilateral sudden deafness, and to explore the changes of central and cortical functions. This study not only has important guiding significance for the treatment and rehabilitation of patients with unilateral sudden deafness, but also expands the research group on auditory perception function and the psychological and neural mechanisms involved in binaural processing, which has important theoretical significance.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Prospective

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • 18-65 years old;
  • patients with unilateral idiopathic sudden sensorineural hearing loss (at least three adjacent frequencies of hearing loss ≥ 30 dB );
  • the first onset;
  • Contralateral hearing is normal; 5) Hearing is cured after treatment

排除标准

  • Sudden deafness with possible definite etiology, such as Meniere's disease, large vestibular aqueduct syndrome, trauma, retrocochlear tumor, etc.;
  • Severe underlying diseases, heart disease, blood disease, pregnancy, breastfeeding, etc.;
  • Suffering from other central diseases that may affect speech perception disorders, such as Alzheimer's disease, etc.;
  • Those who cannot cooperate with the whole study inspection;
  • Those who do not agree to be enrolled or refuse to sign the informed consent form;
  • Those who are using may affect the Medications or treatments for speech perception disorders.

结局指标

主要结局

Change from Baseline Noisy speech recognition rate

时间窗: Change from Baseline Noisy speech recognition rate at admission,6 months, 12 months and 18 months after hearing recovery

The proportion of subjects correctly identifying the target sentence under different masking conditions and different signal-to-noise ratio conditions.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Ma Xin

chief physician

Peking University People's Hospital

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