NCT00457262已完成不适用
Effects of Soy Protein on Serum paraoxonase1 Activity and Lipoproteins in Postmenopausal Women
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 42
- 主要终点
- decrease of LDL,increase of HDL,increase of paraoxonase 1
研究概览
简要总结
paraoxonase 1 is involved to prevent LDL and HDL oxidation,so increase of it's activity leads to lower risk of coronary heart disease.In postmenopausal women ,we have decrease of paraoxonase1 activity and soy proteins may increase paraoxonase1 activity
详细描述
In a double blind clinical randomised clinical trial with parallel design this study was done.52 postmenopausal women were randomly assigned to 50 g/d soy protein or placebo for 10 weeks.serum lipoproteins and pon1 activity were measured at baseline and 10th week.There were significant increase in PON! activity and significant decrease in LDL-C,LDL-C/HDL-C,TC/HDL-C and TG/HDL-C in soy group compare to placebo group.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Double
入排标准
- 年龄范围
- 51 Years 至 57 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Cessation of menes for more than 1 year, elevation for more than 1 year
- •Elevation of FSH level
- •Total cholesterol
- •Triglyceride more than 200 mg/dl
排除标准
- •Chronic disease (heart disease, cancer, diabetes, hepatic, kidney and thyroid disease)
- •Antihypertensive drugs
- •Antibiotics
- •Lipid lowering drugs
- •Sex hormone treatment
- •Hysterectomy
- •Diet rich in soy protein
结局指标
主要结局
decrease of LDL,increase of HDL,increase of paraoxonase 1
次要结局
未报告次要终点
研究者
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