Comparison of High-Flow Nasal Cannula (HFNC) and Conventional Oxygen Therapy (COT) to Diaphragm Function of Post-Upper Abdominal Surgery Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- diaphragm thickness
研究概览
简要总结
This study aims to compare diaphragm thickness, air lung distribution, and several clinical and laboratory parameters on post abdominal surgery patients with conventional oxygen therapy vs high-flow nasal cannula
详细描述
"Approval from Ethical Committee of Faculty of Medicine Universitas Indonesia was acquired prior conducting the study. Subjects were recruited using consecutive sampling method. Subjects underwent upper-abdominal surgery were screened. Eligible and consented subjects were randomized into intervention group (high-flow nasal cannula) and control group (conventional oxygen therapy). Subject and operation characteristics were recorded prior to intervention.
Clinical parameters (vital signs, Borg Score, ICON) were recorded in 10 specific times. diaphragm thickness data using abdominal ultrasonography (USG) and air lung distribution data using Electrical Impedance Tomography were collected in 7 specific times while lactate and blood gas analysis were done 4 times. "
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients from 18 - 65 yrs old,
- •American Society of Anaesthesia (ASA) status I-III,
- •BMI < 30, patent airway,
- •Measurement of Exercise Tolerance before Surgery (METS) Score > 4,
- •P-POSSUM score <10%,
- •agreed to the study
排除标准
- •uncooperative subjects,
- •DNR (do not resuscitate) patients,
- •patients with tracheostomy, pleural effusion, pneumothorax or pulmonary atelectasis
结局指标
主要结局
diaphragm thickness
时间窗: 2 months
diaphragm thickness are measured sequentially by abdominal ultrasonography (mm)
次要结局
- respiratory rate(2 months)
- ICON(2 months)
- heart rate(2 months)
- mean arterial pressure(2 months)
- lactate(2 months)
- partial 02 pressure(2 months)
- electrical impedance tomography (EIT) data(2 months)
- partial carbondioxyde pressure(2 months)
研究者
Sidharta K. Manggala
Consultant, Anesthesiologist
Indonesia University