The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 (PCSK-9) Level in Patients After Coronary Bypass Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 87
- 主要终点
- PCSK-9 Level
研究概览
简要总结
This research add resistance training to patients who undergo cardiac rehabilitation program after coronary bypass surgery, comparing the level of PCSK9 level on that group to another group who receives conventional rehabilitation program (only aerobic exercise)
详细描述
The PCSK9 level measured before and after cardiac rehabilitation program (around 3-4 weeks), and compared between two groups. ELISA method will be used to measure plasma PCSK9 level.
Resistance training will be given by professional trainer in gymnasium of National Cardiovascular Center Harapan Kita supervised by cardiologists, following rules from American College of Sports Medicine guideline regarding to exercise after cardiac event.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •post elective coronary artery bypass surgery
- •> 18 years old
- •sign informed consent
排除标准
- •contraindications of resistance training (unstable angina, uncontrolled blood pressure (systolic > 160 mmHg diastolic > 100 mmHg), acute heart failure, pulmonary diseases, arrhythmia malignant)
- •musculoskeletal pain, visual analog scale >3
- •post congenital heart disease surgery
- •post elective coronary artery bypass surgery with malfunction valves (operated or not)
结局指标
主要结局
PCSK-9 Level
时间窗: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
this outcome measurement will be achieved by taking patient's blood sample after cardiac rehabilitation program. The method that we use to check PCSK-9 level is ELISA method
次要结局
- Low Density Lipoprotein(3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program))
- High-Density Lipoprotein(3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program))
- Systolic Blood Pressure(3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program))
- Body Mass Index(3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program))
- Total Cholesterol(3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program))
- Triglyceride(3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program))
- Fasting Blood Glucose(3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program))
- Diastolic Blood Pressure(3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program))
研究者
Bambang Dwiputra
MD
National Cardiovascular Center Harapan Kita Hospital Indonesia