A Pilot study to assess the effects of beta-blockade on exercise capacity and BNP levels in patients with predominantly diastolic heart failure

south manchester university hospital nhs trust0 个研究点目标入组 40 人开始时间: 2005年4月21日最近更新: 2019年12月16日

适应症

试验速览

暂无简介。

•All patients must satisfy all of the following criteria to be entered into the study.
•1) Evidence or history of clinical heart failure.
•2) Ejection fraction of >45%.
•3) Raised Plasma BNP levels.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range

•1) Clinical evidence of pulmonary or peripheral oedema.
•2) History of asthma or significant reversible chronic obstructive airways disease (reversibility in FEV1 of > 15%)
•3) Hypotension (BP < 100/60)
•4) Significant bradycardia (heart rate < 55 bpm), 2nd or 3rd degree AV block.
•5) History of intolerance to beta-blocker treatment.
•6) Diagnosis of constrictive pericarditis.
•7) Presence of severe peripheral vascular disease.
•10) Myocardial infarction within 3 months prior to enrolment.
•11) Female patients, who are pregnant, breast feeding or planning pregnancy during the course of the study.
•12) Use of any investigational drug within 2 weeks of enrolment into the study.
•13) Recent changes (less than 2 weeks) in cardiac medications other than that instituted by the investigators.
•14) Significant co. morbid disease with a limited prognosis such that likely period of survival from the co morbidity is less than a year.
•15) Clinically significant abnormality identified on screening history, physical examination, laboratory tests, ECG or Echocardiogram, which in the judgment of the investigator would preclude safe completion of the study.
•16) An indication of beta-blocker treatment arises during the study.

发起方

south manchester university hospital nhs trust