NCT03164811已完成不适用
Goal Directed Fluid Therapy Based on Pulse Pressure Variation Compared With Standard Fluid Therapy in Patients Undergoing Complex Spine Surgery: a Randomized Controlled Trial
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- episode of intraoperative hypotension
研究概览
简要总结
The investigators will do the Goal directed fluid therapy by protocolized fluid management in the experimental group, using PPV to guide the fluid administration, compare with standard fluid management in patients undergoing complex spine surgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •elective surgery
- •thoracic/lumbar spine surgery >= 3 levels and duration >= 3 hours
排除标准
- •Cr >2 mg/dl or eGFR < 60 ml/min
- •coronary artery disease, congestive heart failure or cardiac arrhythmia
- •BMI >30 kg/m2
- •hemodynamic unstable, preoperatively
- •uncontrolled hypertension
- •respiratory system compliance < 30 ml/cmH2O
结局指标
主要结局
episode of intraoperative hypotension
时间窗: intraoperative
Blood pressure will be record continuously using arterial catheter in both group. Number of participants and episode of hypotension (defined as SBP \< 90 mmHg or MAP \< 60 mmHg or decrease of SPB \>= 25% from baseline for 5 minutes or need vasopressor) therapy
次要结局
- unit of blood transfusion(intraoperative and up to 24 hours postoperatively)
研究者
研究点 (2)
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