Comparative Evaluation of Clinical Parameters in Early-Stage III Grade A Periodontitis Patients After Insertion of Platelet Rich Fibrin as Step 2 Phase I Therapy in Periodontal Pockets: A Randomized Clinical Trial
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 13
- 试验地点
- 4
- 主要终点
- pocket depth
研究概览
简要总结
Periodontal regenerative therapy has focused on various non-surgical and surgical treatment methods. Platelet-rich fibrin (PRF) has shown to possess multiple uses, including properties that promote healing of both soft and hard tissues. In the present study, we hypothesized that the addition of PRF into periodontal pockets, as an adjunct to conventional scaling and root planing (SRP), would enhance the outcomes of non-surgical periodontal therapy. This split-mouth randomized controlled clinical trial included 26 periodontal pocket sites in 13 patients with periodontitis. The pockets were randomly assigned as either test or control sites. In the test group, PRF was placed as an adjunct to SRP, while the control group received SRP alone. Probing pocket depths (PPD), clinical attachment levels (CAL), gingival recession (GR), plaque index (PI), and gingivitis index (GI) were measured at baseline and at six weeks. The wound healing index was measured during the six-week follow-up period.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •either gender,
- •aged 18 years or older,
- •patients without a medical history of systemic diseases,
- •patient with chronic periodontitis
- •patient with 5 or 6 mm of probing depth
排除标准
- •patients with medical history of systemic disease or bleeding disorders
- •presence of other gingival diseases (such as leukoplakia, lichen planus, pemphigoid disorders, pemphigus vulgaris, herpetic lesions, Necrotizing Ulcerative Periodontitis (NUP)
- •pregnancy
- •history of any drug usage affecting the periodontium for the past six months (such as systemic antibiotic therapy)
- •previous periodontal treatment in the last six months
- •teeth with untreated caries
- •endodontic lesions and grade II or more mobility
- •subjects with acute exacerbation of periodontitis
- •patients with systemic
- •disease or condition that could affect tissue healing (e.g., autoimmune disease)
- •severe furcation involvement (grade II and III)
- •abutment for prosthetic rehabilitation
- •active orthodontic therapy
结局指标
主要结局
pocket depth
时间窗: 6 weeks
Probing pocket depths (PPD), clinical attachment levels (CAL), gingival recession (GR), plaque index (PI), and gingivitis index (GI) were measured
次要结局
未报告次要终点
研究者
Niccoló Giuseppe Armogida
Doctor in Dental Sciences, Principal Investigator
Federico II University