Organisation du Cortex préfrontal ventrolatéral Pour l'Analogie: Approche Bimodale Chez le Sujet Sain et Chez le Patient Ayant un Syndrome Frontal.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 130
- 试验地点
- 2
- 主要终点
- Performance in the implicat task
研究概览
简要总结
Frontal patients are impaired in categorisation and analogical reasoning tasks, and different functional imaging studies from our group have shown the involvement of the prefrontal cortex in categorisation and analogy tasks. The aim of this project is to test our hypotheses about the role of the prefrontal cortex in explicit and implicit categorisation and analogy tasks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy subjects:
- •subject affiliated to national health insurance
- •informed consent signed
- •normal neurological examination
- •subject aged at least 20
- •FTD or PSP diagnostic criteria filled
- •patient affiliated to national health insurance
- •informed consent signed
排除标准
- •Severe psychiatric symptomatology and psychotropic drug use
- •unability to understand or perform the cognitive tasks.
结局指标
主要结局
Performance in the implicat task
时间窗: day of inclusion (one day)
Reaction time and accuracy will be registered for this categorization task. This task will be used in patients with FTD and in healthy controls (n=60). Participants will come only once during one day ot the research centre.
Performance in the Similitude task
时间窗: from inclusion to 4 months after inclusion
Reaction time and accuracy will be recorded while healthy subjects perform this categorization task, after a session of rTMS or during on line TMS (n=40). Participants will come 3 to 5 times at the research centre in a maximum period of 4 months.
次要结局
- recording of EEG(day of inclusion (one day))
- Analysis of MRI(day of inclusion (one day))