A Randomised comparative study to assess efficacy of platelet rich plasma with silver sulphadiazine versus silver sulphadiazine dressing in partial thickness burns
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 40
- 试验地点
- 1
研究概览
简要总结
This study is a randomised comparative trial evaluating the efficacy of platelet rich plasma combined along with with silver sulphadiazine versus silver sulphadiazine alone in partial thickness burns. Silver sulphadiazine is the standard treatment but is associated with delayed healing pain and frequent dressing changes. Platelet rich plasma is an autologous blood product rich in growth factors that enhances angiogenesis epithelialization and tissue regeneration. Forty patients will be randomly assigned to two groups receiving either silver sulphadiazine alone or silver sulphadiazine with platelet rich plasma. Outcomes assessed include time to healing pain score scar score and need for skin grafting, easy pf change of dressing
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- None
入排标准
- 年龄范围
- 2.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •Subjects with a deep partial-thickness burn injury covering 1- 20 % TBSA 2) Patient willing to give informed consent 3) Both sexes with an age of 2-60 years.
- •Subjects who were younger than the legal consenting age must have a legally authorized representative.
- •isolated burn area (not involving head and/or face).
排除标准
- •Subjects with inhalational injury or subjects being on a ventilator.
- •Treatment of the burn with an active agent before study entry.
- •Clinically infected burn 4)Diagnosed underlying disease(s) (e.g., HIV/AIDS, cancer, and severe anemia) Judged by the investigator to be a potential interference in the treatment.
- •Use of immunosuppressive agents, radiation, or chemotherapy within the past 30d.
- •Subjects with physical and/or mental conditions who are not expected to comply with the investigation.
- •Pregnancy 8)Patient with haematological or coagulation disorders 9)Patients with any chronic skin disease 10) Electric or chemical burns.
研究者
Dr Anoosha Tresa Pius
bangalore medical college