The Coastal Exposome: a Study of Sea Air Inhalation and Possible Links to Health
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 67
- 试验地点
- 2
- 主要终点
- nose swabs: respiratory microbiome and biogenics profile
研究概览
简要总结
The research aims to understand oceans as crucial contributors to human health in coastal environments. Oceans produce marine spray aerosols that contain a mixture of microbiota and natural biological molecules (biogenics).
详细描述
The primary outcome envisioned consists of 2 goals.
- In this study, the first objective is to determine whether the microbiota and biogenic molecules found in sea air are also found in the nasal swabs of the participants. In this way, the investigators will gain an understanding of which sea air components are inhaled by humans and how this changes over time. Besides, the difference in microbiome between the inland and coastal population will be investigated.
- Second, the investigators want to get an idea of whether these inhaled sea air components have an effect on certain pathways in the human body. In the in vitro study with cell lines, effects were already seen of sea air exposure on certain pathways in the body. Now the second goal of this study, is to see if changes in immunity biomarkers are seen in vivo in humans. The Investigators will do this by taking VAMS blood samples from the participants.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •healthy participants between 18 and 50 years old
排除标准
- •people with a medical condition
- •people younger than 18 and older than 50
研究组 & 干预措施
reference group coast
This group lives at the coast the whole year round
干预措施: no intervention (Other)
reference group inland
This group lives inland all year round.
干预措施: no intervention (Other)
结局指标
主要结局
nose swabs: respiratory microbiome and biogenics profile
时间窗: 4 times during the 8 week study period
DNA from the nose swabs will be analysed using sequencing for analyzing the microbiome. Biogenics on the swabs will be analysed as well, to get an idea of what molecules and microbiota from the sea air are inhaled. This will happen with UPLC-QTOF-MS.
VAMS blood samples: cytokines
时间窗: 4 times during the 8 week study period
Cytokines will be measured in blood samples to link the sea air exposure to the human health. A multiplex kit will be used to measure 20 cytokines.
次要结局
未报告次要终点