The Effectiveness of a Diet With Beef as Key Protein Component Versus a Plant-Based Diet to Support Integrated Muscle Protein Synthesis Rates in Healthy Older Individuals
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 32
- 试验地点
- 1
- 主要终点
- Integrated muscle protein synthesis rate in rested leg
研究概览
简要总结
Muscles are composed out of proteins. These proteins in turn are composed out of smaller building blocks, called amino acids. By consuming a sufficient amount of dietary protein, a sufficient amount of amino acids become available to build new muscle proteins. The body's ability to build these new muscle proteins is of great importance to maintain muscle strength and function.
Previous research suggests that a meal containing proteins from meat results in a better stimulation of the body's ability to build muscle proteins, when compared to a meal containing only plant-based proteins. However, these previous studies have only been performed following the ingestion of a single meal. As a result it is currently unknown how the muscles respond to a more prolonged ingestion of a diet containing animal/meat products, in comparison to a plant-based diet. Therefore, this study aims to investigate how fast new muscle proteins are being build when consuming a diet containing animal/meat products, in comparison to a plant-based (vegan) diet.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 65 Years 至 85 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Male or female sex
- •Aged between 65 and 85 y inclusive
- •BMI between 18.5 and 30 kg/m2 inclusive
排除标准
- •Not willing to consume meat/animal-based products during the study period
- •Any food allergies (e.g. milk, gluten, etc.)
- •Participating currently or in the 3 months prior to the study in a structured progressive exercise program.
- •History of cardiovascular, respiratory, gastrointestinal, urogenital, neurological, psychiatric, dermatologic, musculoskeletal, metabolic, endocrine, haematological, immunologic disorders, allergy, major surgery and/or laboratory assessments which might limit participation in or completion of the study protocol, interfere with the execution of the experiment, or potential influence the study outcomes (to be decided by the study team and responsible physician)
- •Diagnosed with phenylketonuria (PKU)
- •Donated full blood 3 months prior to test day
- •Use of any medications that interferes with study participation and/or outcomes (i.e. corticosteroids, non-steroidal anti-inflammatories, gastric acid suppressing medication) as assessed by the study team and responsible medical doctor.
- •Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants
- •Fasting blood glucose >7 mmol/L
研究组 & 干预措施
MEAT-PLANT
Participants will be subjected to a 10-day diet containing meat and animal products, followed by a 10-day diet containing plant products. During the interventional period participants will perform unilateral lower limb resistance exercise.
干预措施: Meat diet (Other)
MEAT-PLANT
Participants will be subjected to a 10-day diet containing meat and animal products, followed by a 10-day diet containing plant products. During the interventional period participants will perform unilateral lower limb resistance exercise.
干预措施: Plant diet (Other)
PLANT-MEAT
Participants will be subjected to a 10-day diet containing plant products, followed by a 10-day diet containing meat and animal products. During the interventional period participants will perform unilateral lower limb resistance exercise.
干预措施: Meat diet (Other)
PLANT-MEAT
Participants will be subjected to a 10-day diet containing plant products, followed by a 10-day diet containing meat and animal products. During the interventional period participants will perform unilateral lower limb resistance exercise.
干预措施: Plant diet (Other)
结局指标
主要结局
Integrated muscle protein synthesis rate in rested leg
时间窗: The 2 intervention periods over which FSR is determined will each last 10 days
The main study endpoint will be the difference in muscle protein synthesis rates in the non-exercised leg, between the plant-based diet and the meat diet, expressed as FSR (%/day).
次要结局
- Blood inflammatory markers(The 2 intervention periods after which the outcomes are determined will each last 10 days)
- Blood amino acid profile(The 2 intervention periods after which the outcomes are determined will each last 10 days)
- Blood pressure(The 2 intervention periods after which the blood pressure is determined will each last 10 days)
- Integrated muscle protein synthesis rate in exercised leg(The 2 intervention periods over which FSR is determined will each last 10 days)
- Blood glucose(The 2 intervention periods after which the outcomes are determined will each last 10 days)
- Blood insulin(The 2 intervention periods after which the outcomes are determined will each last 10 days)
- Blood lipid profile(The 2 intervention periods after which the outcomes are determined will each last 10 days)