Validation of Plasma Endostatin for Predicting Renal Outcome From Acute Kidney Injury Induced by Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Renal outcme
研究概览
简要总结
Introduction: Acute kidney injury (AKI) occurs up to 50% of patients admitted to intensive care unit. Plasma Endostatin, released from basement membrane of Bowman's capsule, rises early during AKI.
Aim of Work: To investigate the role of the plasma endostatin in the outcome prediction (renal recovery, ICU stay, mortality) of acute kidney injury in patients with sepsis.
Methods: a prospective, observational single center study on 40 patients with Sepsis at the Critical Care Department, Cairo University hospitals between March 2019 and November 2019. Serum plasma endostatin was measured at the day of admission & every 48hrs (3 samples). APACHE II, SOFA scores were calculated. Forced diuresis was used if indicated.
详细描述
The study was conducted on 40 patients with sepsis who admitted in the Critical Care department of Cairo University.
The sepsis is identified according to surviving sepsis campaign guidelines with use of SOFA score to establish the diagnosis.
The patients divided into 2 groups the first group included 25 patients who developed AKI as defined by KDIGO guidelines and the other group included 15 patients as a control group.
The Plasma Endostatin level is sampled in the first 24 hours of diagnosis of AKI, the estimation of plasma Endostatin level done by ELISA technique.
The results were presented in form of: descriptive, analytical and comparative data between the groups of study.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with sepsis defined According to Surviving Sepsis Campaign 2016 sepsis: Suspected or documented infection in addition to increase in SOFA score 2 points or more from the baseline
- •The patients will be followed for development of acute kidney injury (AKI) defined according to criteria established by Kidney Disease Improving Global Outcome guidelines (KDIGO) 20129 which includes any of the following criteria:
- •Increase in serum creatinine by > 0.3 mg/dl within 48 hours; or
- •Increase in serum creatinine to > 1.5 times baseline, which is Known or presumed to have occurred within the prior 7 days; or
- •Urine volume < 0.5 ml/kg/h for 6 hours.
排除标准
- •Critically ill patients with known history of CKD.
- •Patients on RRT ( intermittent or continuous)
- •Post renal AKI.
- •Not known history of nephrotoxic drug intake.
- •Patient with contrast induced nephropathy
- •Patients with cardiogenic shock who developed AKI.
结局指标
主要结局
Renal outcme
时间窗: 7 days
Number of participants who have recovered renal functions \& those who needed Renal replacement therapy
次要结局
未报告次要终点
研究者
Mostafa Farouk
clinical professor
Cairo University