Developmental Coordination Disorder: Integrating Brain Imaging and Rehabilitation to Improve Outcomes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 115
- 试验地点
- 2
- 主要终点
- Canadian Occupational Performance Measure
研究概览
简要总结
Developmental coordination disorder (DCD) affects 5-6% of the school-age population, equating to ~400,000 children, or 1-2 students in every Canadian classroom. Children with DCD find it hard to learn motor skills and perform everyday activities, such as getting dressed, tying shoelaces, using utensils, printing, riding a bicycle, or playing sports. Researchers and clinicians do not know what causes DCD or why children with DCD struggle to learn motor skills. Using MRI, this study will increase understanding of how the brain differs in children with/without DCD and determine if rehabilitation can change the brain and improve outcomes of children with the disorder.
详细描述
SPECIFIC OBJECTIVES AND HYPOTHESES
The proposed study proposed is designed to test the overall hypothesis that, compared to typically-developing children, children with DCD (+/- ADHD) will show differences in brain structure and function, and that rehabilitation will be associated with brain differences that reflect improvement of motor function. The investigators will address three specific objectives:
Objective 1: To characterize structural and functional brain differences in children with DCD and typically-developing children.
Hypothesis: Compared to typically-developing children, the investigators expect that children with DCD will show smaller cerebellar volume, differences in microstructural development in motor, sensory and cerebellar pathways, decreased strength of connectivity in resting, default mode, and motor networks. Children with DCD+ADHD will show poorer function in frontal and parietal areas compared to children with DCD (Langevin et al., 2014).
Approach: The investigators will use magnetic resonance (MR) imaging and advanced MR techniques to characterize brain structure and function; the investigators will use morphometry to measure cerebral and cerebellar volumes, diffusion tensor imaging (DTI) to assess microstructural development, functional connectivity MRI to measure connectivity in different brain networks, and fMRI to explore patterns of brain activation during a mental rotation task.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 8 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •children with suspected DCD based on history and results of motor testing (MABC-2) and parent questionnaire (DCDQ) and interview
- •typically developing children who score at or above 25th percentile on MABC-2
排除标准
- •a medical condition that could explain motor problem, such as cerebral palsy, significant intellectual disability, or visual impairment
- •children with ferrous metal in their body
结局指标
主要结局
Canadian Occupational Performance Measure
时间窗: 12 weeks
Children will rate performance and satisfaction (10 point Likert scale) of their three motor goals
diffusion tensor imaging
时间窗: 12 weeks
fractional anisotropy and diffusivity (mean, axial, and radial)
次要结局
- functional magnetic resonance imaging(12 weeks)
- morphometry(12 weeks)
- Performance Quality Rating Scale(12 weeks)
- functional connectivity(12 weeks)
- Bruininks Osteretsky Test of Motor Proficiency(12 weeks)
研究者
Jill Zwicker
Principle Investigator
University of British Columbia