Effects of Coffee Roasting on Blood Sugar Levels in Healthy Humans
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 2
- 主要终点
- Changes in Blood Glucose
研究概览
简要总结
The present study determined the effects light, medium, and dark roasted, brewed coffees on blood glucose responses in normal (n = 19) subjects.
详细描述
This is a single-blinded, randomized partial block design conducted over 6 weeks in two parts.
In part 1 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a beverage containing 50 g of glucose.
In part 2 (3 weeks), participants were randomly assigned to consume four beverages: a placebo containing water and caramel color, light, medium, or dark roast coffee before, during, or after consumption of a standardized breakfast (corn flakes cereal + skim milk) containing 50 g of glucose.
In each part, fasting and postprandial glucose profiles were determined.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
盲法说明
Subjects provided placebo and coffee beverages in a color coded bottles
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl.
排除标准
- •Age 18-64 years old with BMI less than 29 and fasting blood glucose less than 125 mg/dl.
- •Weight less than 110 pounds (55 kg)
- •Pre-existing health conditions, such as:
- •High cholesterol
- •Hypertension
- •Cardiovascular disease
- •Gastrointestinal motility disorders
- •Hypo- or hyperthyroidism
- •Renal disease
- •Liver disease, including hepatitis B or C, cholestasis, cirrhotic liver disease, or non-alcoholic fatty liver disease
- •Chronic or acute pancreatitis
- •Diabetes type 1 or 2
- •Insulin resistance
- •Polycystic ovary syndrome
- •Food allergies or intolerances to coffee/caffeine/dairy/corn-based cereals.
- •Currently taking prescription medication
- •Current smoker
- •Consumes more than 3 alcoholic beverages per day
- •Pregnant or breastfeeding
- •Not willing to take their own blood samples with finger sticks
结局指标
主要结局
Changes in Blood Glucose
时间窗: 6 weeks
Each week, fasted baseline and postprandial measurements taken out to 240 minutes
次要结局
- Changes in Glucose Area Under the Curve(6 weeks)
研究者
Gabriel Keith Harris
Associate Professor of Food Science
North Carolina State University