Different Effects of Two Anesthetic Techniques on Renal Function During the Perioperative Period of Cardiac Surgery in Children
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- renal blood flow
研究概览
简要总结
This study evaluates Different effects of two anesthetic techniques on renal function during the perioperative period of cardiac surgery in children.
详细描述
Acute kidney injury is one of the major complications after heart surgery, which increases the mortality of patients. Therefore, early prevention and detection of acute kidney injury is particularly important. In recent years, more and more studies have shown that both sevoflurane, an inhaled anesthetic widely used in clinical practice, and propofol, an intravenous anesthetic, have protective effects on kidneys. The aim of this study was to investigate the perioperative effects of two different anesthetic techniques on renal function for pediatric cardiac surgery.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 1 Minute 至 3 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •children with congenital heart disease
- •<3 years of age
排除标准
- •preoperative renal insufficiency;
- •renal malformation, kidney absence
结局指标
主要结局
renal blood flow
时间窗: 2 days
Changes of blood flow information of renal artery was obtained before anesthesia induction, after anesthesia, at the end of operation and 24 hours after surgery, unit(cm/s)
次要结局
- creatinine(3 and 4 days)
- Mean arterial pressure(2 days)
- cardiopulmonary bypass (CPB) time(24 hours)
- neutrophil gelatinase-associated lipocalin , NGAL(2 days)
研究者
Huiying Shao
The attending anesthesiologist
Children's Hospital of Fudan University