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临床试验/NCT07198308
NCT07198308已完成不适用

Association Between Blood Glucose Indicators and Heart Rate Variability in Non-diabetic Critically Ill Patients: a Single-center Prospective Study

Shanghai Zhongshan Hospital1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2025年10月1日最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
20
试验地点
1
主要终点
Correlation between glucagon and HRV in non-diabetic critically ill patients

研究概览

简要总结

Heart rate variability (HRV) is a simple way to check how well the body's automatic nervous system is working. It does this by looking at how the heart rate changes in the electrocardiogram. HRV can be divided into time domain and frequency domain. Time domain indicators assess the tone of the autonomic nerves. Frequency domain indicators reflect the regulation of the sympathetic and parasympathetic nerves. An imbalance of the body's nervous system can be reflected by HRV. Stress hyperglycemia (SIH) is when your blood glucose levels go up because of an acute disease. This is usually related to the body's stress response, but if your blood glucose levels go up too much, it can lead to complications. A high blood sugar level caused by stress is common in intensive care units. There is a strong link between this and the death rate and how long patients stay there. There are lots of nerve endings in the pancreas. Nerve fibres control the way islet α/β cells work to keep the right amount of glucose in the blood. We know that the pancreatic nerve is important for controlling blood glucose levels, but we don't fully understand how it does this.

研究设计

研究类型
Observational
观察模型
Case Only
时间视角
Prospective

入排标准

年龄范围
18 Years 至 99 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Aged from 18 to 99 years old
  • •Informed consent has been signed

排除标准

  • •Under 18 years old
  • •Diagnosed with diabetes either prior to or during hospitalization
  • •Missing HRV values
  • •Missing blood glucose and random insulin values

结局指标

主要结局

Correlation between glucagon and HRV in non-diabetic critically ill patients

时间窗: From enrollment to completion of indicator testing (within 24 hours)

次要结局

  • The correlation between blood glucose and random insulin levels and HRV in non-diabetic critically ill patients(From enrollment to completion of indicator testing (within 24 hours))

研究者

发起方
Shanghai Zhongshan Hospital
申办方类型
Other
责任方
Sponsor

研究点 (1)

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