Preterm Birth Cohort Study in Guangzhou
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 5,000
- 试验地点
- 1
- 主要终点
- Neurodevelopment at early childhood
研究概览
简要总结
The Preterm Birth Cohort Study in Guangzhou (PBCSG) aims to explore the impact of genetic and environmental factors including life styles on preterm birth, to examine the interaction effect between these factors, and to follow up the short-term and long-term outcomes of preterm childrens.
详细描述
Preterm birth has become the leading cause of neonatal death and the second leading cause of death among children under five years of age. Preterm childrens are more susceptible to adverse health problems including brain injury and neurodevelopment delay, and are at risk of chronic diseases which could impair the health status and life quality later in life. However, the causes of preterm birth is still not clear, and there are no effective prediction and preventive strategies. The Preterm Birth Cohort Study in Guangzhou (PBCSG) will collect the epidemiological,clinical information and biological specimens including maternal blood,cord blood, placenta, children's blood and stool samples of preterm childrens and their mothers. More importantly, childrens' health status, physical and neurodevelopment will be followed up to late childhood and adolescence. The preterm birth cohort would help to explore the mechanism of preterm birth and to examine the short- and long-term influence of preterm birth on physical health and neurodevelopment of childrens.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Born before 37 weeks of gestation
- •Born in Guangzhou Women and Children's Medical Center
- •Intended to remain in Guangzhou for more than 3 years
排除标准
- •Multiple birth
- •With major congenital abnormalities
结局指标
主要结局
Neurodevelopment at early childhood
时间窗: At age of 1 year
Assessed by using the Gesell Developmental Schedules, which include adaptive, gross motor, fine motor, language, and social function domains. Higher score in each domain is considered a better outcome, while no more than 85 is defined as suspected development retardation
次要结局
- Weight changes during childhood and adolescence(At birth, age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 year)
- Intelligence quotient of offspring(At age of 6 years old)
- Height changes during childhood and adolescence(At birth, age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 year)
- Changes of body fat percentage during early childhood(At age of 3 years, 6 years, 12 years and 18 years old)
- Change of intestinal flora during early childhood(At age of 6 weeks, 6 months, 1 year, 3 years, 6 years, 12 years and 18 years old)
- Changes of bone density during early childhood(At age of 3 years, 6 years, 12 years and 18 years old)
研究者
Xiu Qiu
Director of the Born in Guangzhou Cohort Study
Guangzhou Women and Children's Medical Center