Effects of High Flow Nasal Cannula on Exercise Endurance in Patients With COPD
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 15
- 试验地点
- 2
- 主要终点
- exercise time with high flow nasal cannula
研究概览
简要总结
Ventilation limitation has a significant adverse effects on cardiovascular function and cerebral oxygenation during exercise in patients with COPD. High flow nasal cannula (HFNC) has been shown to improve ventilation by washing out the anatomical dead space and permitting a better gas exchanges. Moreover, it is able to ensure the desired inspired oxygen fraction (FiO2) even at high level of patient's minute ventilation by minimizing the room air entrainment. The effects of HFNC on exercise performance in terms of hemodynamic changes and exercise endurance in COPD patients remain unclear. The primary purpose of this study is to examine the effects of HFNC on the exercise endurance in COPD patients. The investigator's secondary purpose is to investigate whether HFNC could improve efficiency of ventilation, leading to an improvement of hemodynamic and cerebral oxygenation response.
详细描述
This is a randomized crossover study. Patients who have been diagnosed as COPD will be recruited from outpatient department. After signing informed consent form, patients undertake an incremental exercise test and two constant load exercise at the 70% of maximum workload achieved at a previous incremental exercise test on arm ergometer in two separate days. The constant load tests will be performed with HFNC and with nasal cannula at the same inhaled oxygen fraction in random order. The hemodynamics CO, SV, EF of all subjects during exercises will be measured by a bioelectrical impedance device (Physioflow), and cerebral oxygenation status (oxygenated hemoglobin (O2Hb), deoxygenated hemoglobin (HHb), total hemoglobin (tHb) was measured by a near infrared spectrophotometer (NIRS).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •with diagnosis of COPD
- •OPD patients
- •has no AE (within 1 month)
- •not receiving any O2 therapy at home
- •no smoking or quick
排除标准
- •unstable hemodynamics at resting
- •orthopadeic or neurologic problems that limited exercise
结局指标
主要结局
exercise time with high flow nasal cannula
时间窗: end of the exercise test in the session of constant-load exercise test with high flow nasal cannula oxygen device
the total duration that subjects performed constant-load exercise test with high flow nasal cannula oxygen device
exercise time with nasal cannula
时间窗: end of the exercise test in the session of constant-load exercise test with nasal cannula oxygen device
the total duration that subjects performed constant-load exercise test with nasal cannula oxygen device
次要结局
- Difference in muscle tissue oxygenation(Baseline and 48 hours after baseline ])
- Difference in cardiac output(Baseline and 48 hours after baseline ])
- Difference in stroke volume(Baseline and 48 hours after baseline ])
- Difference in cerebral tissue oxygenation(Baseline and 48 hours after baseline ])
研究者
Chen Yen-Huey
assistant professor
Chang Gung University