NCT05518422撤回早期 1 期
Role of Endothelin-1 Modulating Insulin-stimulated Blood Flow and Sympathetic Nervous System Activity in Obesity
适应症
干预措施
相关药物
试验速览
- 阶段
- 早期 1 期
- 状态
- 撤回
- 主要终点
- Amount of muscle sympathetic nerve activity (MSNA)
研究概览
简要总结
The aim of this project is to determine role for ET-1 in individuals with obesity.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •18-55 years of age
- •Obese (BMI ≥30 kg/m2)
排除标准
- •Female sex
- •Current smoking/Nicotine use
- •Nerve/neurologic disease
- •Cardiovascular, hepatic, renal, respiratory disease
- •Blood pressure ≥140/90 mmHg
- •Vigorous exercise >3 times/week
- •Communication barriers
- •taking any medications known to affect metabolic, respiratory, cardiovascular, and/or autonomic
研究组 & 干预措施
Oral Bosentan
Experimental
干预措施: Hyperinsulinemic, euglycemic infusion (Drug)
结局指标
主要结局
Amount of muscle sympathetic nerve activity (MSNA)
时间窗: Change from baseline at minute 60
MSNA burst incidence (bursts/100 heart beats)
Amount of leg blood flow
时间窗: Change from baseline at minute 60
Measured with Doppler ultrasound (mL/min)
次要结局
未报告次要终点
研究者
Jacqueline K Limberg, PhD
Assistant Professor
University of Missouri-Columbia
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