CTRI/2018/04/013409已完成不适用
A comparison of propofol, etomidate and Ketofol means ketamine propofol 1:3 ratio as induction agentA Randomized comparative clinical study
Department of anaesthesiology1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2016年12月16日最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- comparision of haemodynamics in three groups
研究概览
简要总结
comparing propofol,etomidate and ketofol as an induction agent and to compare haemodynamic changes during induction and intubation with etomidate, propofol and ketamine +propofol (ketofol) and to evaluate any adverse effects of study drugs.We Concluded that combination of ketamine plus propofol has better haemodynamic stability than etomidate and propofol as an induction agent with no side effects. Hence, combination proved to be significantly better than either propofol or etomidate alone
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 60.00 Year(s)（—）
- 性别
- All
入选标准
- •American society of Anaesthesiologist grade I and II of either sex, weighing 35-70kg elected for general surgeries under general anaesthesia.
排除标准
- •Patients with history ofadrenal insufficiency, asthma,hypertension,suspected difficult airway, receiving general anaesthesia during the previous week,receiving steroid during the past 6 months,sensitivity to etomidate, propofol or ketamine,sensitivity to egg and soya,pregnancy, Morbidly obese,chronic inflammatory diseases and serious psychiatric,endocrine or neurological illnesses.
结局指标
主要结局
comparision of haemodynamics in three groups
时间窗: Haemodynamics were recorded baseline value,after induction,0 min after intubation,1 minute after intubation, 3 min after intubation, 5 min after intubation and 10 min after intubation
次要结局
- comparison of side effects and any adverse effects(any adverse effects of drug like pain on injection and myoclonus movement was seen during induction)
研究者
研究点 (1)
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