Psorcast Study: A Smartphone-based Study of Psoriasis and Psoriatic Arthritis
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 1,000
- 试验地点
- 2
- 主要终点
- Results of participant self-assessment surveys
研究概览
简要总结
The purpose of this study is to understand variation in the symptoms of psoriasis and psoriatic arthritis using simple, scalable smartphone-based measurements. This study uses an iPhone app to record these symptoms through questionnaires and sensors.
详细描述
Psoriatic disease exhibits a spectrum of symptoms and can transition from psoriasis (PsO), largely affecting the skin, to psoriatic arthritis (PsA) involving widespread musculoskeletal inflammation. Early detection of the PsO-to-PsA transition and rapid administration of effective treatment is essential, as a delay in diagnosing PsA by as little as 6 months can lead to irreversible joint damage. This "ticking clock" paradigm drives the need for frequent monitoring and effective therapeutic intervention as early as possible to attenuate or possibly prevent disease progression. Using a suite of smartphone-based measurements in an app called Psorcast (psoriasis forecasts), we aim to aggregate weekly, symptom measurements from participants in a remote, longitudinal observational study to map the trajectories of treatment response and disease progression. In this study, we will explore measurements of psoriatic disease activity at least an order of magnitude more frequently (weekly vs. quarterly) than standard clinical practice or clinical trial designs. This study is not meant to provide a medical diagnosis, treatment, or medical advice. It is meant to provide a scalable, inexpensive, non-invasive and frequent measure and tracking of psoriasis and psoriatic arthritis for research purposes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult age 18 and older who consent to participate in the study
- •Own a compatible iPhone or iPod Touch device running iOS 12.2 or above
- •Be able to read and understand an official language of the country of participation
排除标准
- •Age 17 years or younger
- •Not a resident of the a country where the app is approved for use
- •Not have a personal (i.e., not shared) iPhone (4s or newer running iOS 8.0 or later)
- •Not be able to read and understand an official language of the country of participation
结局指标
主要结局
Results of participant self-assessment surveys
时间窗: Through study completion, an average of 2 years
Results of participant self-assessment surveys will be analyzed using descriptive statistics. These results may also be compared with other intervention results.
Computer vision features from Finger/Toe Photos
时间窗: Through study completion, an average of 2 years
The investigators apply visual processing and classifier algorithms to segment nails and joints from hand and foot photos. These results may also be compared with other intervention results.
Computer vision features from Psoriasis Area Photo assessment
时间窗: Through study completion, an average of 2 years
The investigators apply visual processing and classifier algorithms to analyze the images from the Psoriasis Area Photo assessments. These results may also be compared with other intervention results.
Gyroscope and accelerometer sensor measurements from Digital Jar Open assessment
时间窗: Through study completion, an average of 2 years
The investigators examine rotational features from gyroscope and accelerometer sensors. The investigators apply feature selection and classifier algorithms to analyze these data. These results may also be compared with other intervention results.
Quantification and distribution of self-reported painful joints
时间窗: Through study completion, an average of 2 years
The investigators will quantify the self-reported painful joints and, in particular, compare to measurements from the 30-sec Walk and Digital Jar Open to identify correlations. These results may also be compared with other intervention results.
Body surface area and location from the Psoriasis Draw assessment
时间窗: Through study completion, an average of 2 years
The investigators will quantify body surface area and psoriasis area hotspots across the cohort. These results may also be compared with other intervention results.
Gyroscope and accelerometer sensor measurements from 30-sec Walk assessment
时间窗: Through study completion, an average of 2 years
The investigators examine step-dependent and sequence-dependent features from gyroscope and accelerometer sensors. The investigators apply feature selection and classifier algorithms to analyze these data. These results may also be compared with other intervention results.
次要结局
- App usage data for assessment of participant engagement(Through study completion, an average of 2 years)