A study of Efficacy and safety of oral tofacitinib vs methotrexate in management of moderate to severe chronic plaque psoriasis

one0 个研究点目标入组 0 人开始时间: 待定最近更新: 2023年6月26日

试验速览

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•1.Age less than 18 or more than 70 years
•2.Individuals with severe anaemia, leukopenia(lymphocytes <500 cells/mm3, ANC <500 cells/MM3,Hemoglobin <9g/dl), pre-existing liver diseases, bone marrow pathologies causing cytopenia,
•3.Individuals with heavy alcohol consumption ( >14 units/week) or heavy smokers.
•4.Individuals on concomitant medications such as high dose vitamin D, oral/topical steroids, PUVA, Acitretin, Dapsone, Sulfamethoxazole, Trimethoprim
•5.Pregnant and lactating women
•6.Patient having pre-existing uncontrolled Diabetes mallitus , Hypertension
•7.Patients who have taken any immunosuppressant drugs, homeopathic/herbal medications in last 4 weeks.
•8.Patients with malignancies/ history of malignancy.
•9.Patients with risk/history of thromboembolism, cardiovascular accidents.
•10.Patients with active infection, active/latent tuberculosis.
•11.Patients found to have abnormal laboratory parameters that would increase the risk of adverse effect

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