The EC90 of Remifentanil Blunting Hemodynamic Changes to Head Fixation in the Patients Undergoing Neurosurgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- mean arterial blood pressure
研究概览
简要总结
The purpose of this study is to estimate the EC90 of remifentanil blunting hemodynamic changes to head fixation in the patients undergoing neurosurgery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients undergoing neurosurgery that require head fixation with mayfield head holder
- •patients who agree to our study
排除标准
- •patients who don't agree to our study
- •BMI<16.0 or BMI>30
- •cardiovascular disease, pulmonary disease, renal disease
- •alcoholic abuser or drug abuser
- •patients who takes any drug having an influence on cardiovascular system or sympathetic nervous system
- •any use of local anesthetics or drugs which have an influence on cardiovascular system from beginning of induction to peri-fixation period
研究组 & 干预措施
neurosurgery with fixation
干预措施: remifentanil (Drug)
结局指标
主要结局
mean arterial blood pressure
时间窗: peri-fixation periord
mean arterial blood pressure will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation.
heart rate
时间窗: peri-fixation periord
heart rate will be recorded at 2 minutes before fixation, 1 minute before fixation, highest value during immediately post-fixation periord, 1 minute after fixation, 2 minutes after fixation, 3 minutes after fixation, 4 minutes after fixation and 5 minutes after fixation.
次要结局
未报告次要终点
研究者
Jae-Hyon Bahk, MD, PhD
professor
Seoul National University Hospital