Strategies for rapid acclimatization to high altitude – using different modalities
试验速览
- 阶段
- 2 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 200
- 试验地点
- 2
- 主要终点
- Incidence of Acute Mountain Sickness
研究概览
简要总结
Exposure at high altitude (HA) induced hypobaric hypoxia is known to deteriorate health and decrease performance. The aim of the study is to develop of Rapid Acclimatization Schedule for HighAltitude in Western sector using different modalities. 400 volunteers within the age range of 20-40 years will be recruited. The volunteers will be randomized into 4 different groups - Control, Drug treated (Acetazolamide), Stay at Moderate Altitude (Short duration) and Intermittent Hypoxia Exposure (IHE). After recording their baseline parameters at Sea Level area they will be inducted to Stage - I HA by air followed by Stage - II HA by road. In all stages differentphysiological, physical and biochemical parameters would be assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant and Investigator Blinded
入排标准
- 年龄范围
- 20.00 Year(s) 至 40.00 Year(s)（—）
- 性别
- Male
入选标准
- •a) Age group: 20 – 40 years b) Medical history: SHAPE – I.
排除标准
- •a) Smokers b) Drinker c) Prior induction to HA d) Medical history of any sort.
结局指标
主要结局
Incidence of Acute Mountain Sickness
时间窗: During the initial days after ascent to high altitude area.
次要结局
- Exercise Capacity at High Altitude(After 48 and 72 hours after reaching high altitude area.)