Muscle Atrophy, Physical Performance and Glucose Tolerance Post Stroke
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 100
- 试验地点
- 3
- 主要终点
- Change in body composition
研究概览
简要总结
Stroke, a leading cause of disability in the aging population, increases the risk for diabetes, subsequent stroke recurrence, and cardiovascular disease complications. The downsizing of private and federal health care resources, along with the anticipated increase in stroke rates as our population ages, mandate that alternative strategies be developed to reduce the public health burden of stroke. This pilot study may facilitate our knowledge of the timing of paretic leg muscle atrophy, fiber type shift, and the progression of worsening of glucose tolerance after stroke. Knowledge of the skeletal muscle changes occurring in the sub-acute stroke period is essential to create new guidelines incorporating exercise rehabilitation, much like cardiac rehabilitation, in order to facilitate and improve the health care of veteran stroke survivors.
详细描述
The vast majority of cerebrovascular accidents are reported in persons older than 55 years of age and occur in over 780,000 persons each year in the U.S. As our adult population ages, the number of strokes in the United States is anticipated to double, reaching nearly 1.5 million annually by the year 2050. Following stroke, patients remain at continued high risk for recurrent stroke with almost a third of them suffering recurrent stroke within 5 years, even despite optimal medical management. Age and cardiac disease are among the most important longitudinal predictors of cardiovascular health outcomes and survival after stroke. Notably, 75% of chronic stroke survivors have residual disability emphasizing the need for rehabilitation strategies.
Knowledge of the skeletal muscle changes that occur in the early phases after stroke is essential to create new guidelines which incorporate exercise rehabilitation, much like cardiac rehabilitation, in order to facilitate and improve the health care of stroke survivors.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Men or women 21 years of age or older
- •BMI between 20-50 kg/m2
- •Presenting within a month after stroke onset with residual hemiparetic deficit
- •Patients must have adequate language and neurocognitive function to participate in testing and give adequate informed consent
排除标准
- •Patients deemed too disabled to participate in physical therapy, or patients with minimal deficits, or patients who fully recovered after their stroke, in which physical therapy is not necessary
- •Unstable angina, CHF, severe PAD
- •Dementia or untreated major depression
- •Severe receptive or global aphasia
- •Heavy alcohol use defined by greater than 3 oz. liquor, 12 oz of wine or 32 oz of beer daily
- •Muscle biopsy Exclusion Criteria:
- •anti-coagulation therapy with heparin, warfarin, or lovenox (anti-platelet therapy is permitted)
- •bleeding disorder
- •allergy to lidocaine
结局指标
主要结局
Change in body composition
时间窗: change in muscle mass from baseline to 3 months
Muscle mass
次要结局
- Change in physical function(change in walk distance from baseline to 3 months)
- Change in glucose(change in glucose from baseline to 3 months)
研究者
Alice S. Ryan, PhD
Professor of Medicine
Baltimore VA Medical Center