NCT00259246已完成不适用
Fasting and Postprandial Response After Infusion of Saline, PYY1-36 and PYY3-36 and Effects on Appetite, Energy Intake and Energy Expenditure in Overweight/Obese Compared to Normalweight Subjects
适应症
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 主要终点
- Appetite
研究概览
简要总结
The aim of the study is to compare fasting and postprandial PYY levels between overweight/obese and lean subjects during and after an infusion of saline, PYY1-36 or PYY3-36 and to evaluate the efects on appetite, energy intake and energy expenditure.
详细描述
The study is a randomised dobbelblinded placebo controlled study with 24 male subjects ( 12 lean and 12 overweight/obese subjects). VAS scores are used to assess appetite and two ad libitum meals are served in the hours following the infusion. Energy expenditure is measured by ventilated hood system and blood is sampled during part of the study day.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- Single
入排标准
- 年龄范围
- 20 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Normal weight (BMI: 18-23 kg/m2) or 12 overweight/obese (BMI: 27-40 kg/m2)
- •Body weight fluctuations < 5 kg over the past 2 months.
- •Blood pressure normal to mildly hypertensive (<159/99 mm Hg)
- •Non-elite athletes and not planning to change physical activity during the study.
排除标准
- •Any physiological or psychological illnesses that could influence the study results
- •Regular use of medicine
- •Smoking defined as <1 cigarette per day.
- •Substance abuse or dependence.
- •Blood donation within the past 3 months before entering the study
- •Drinking >21 alcoholic units/week.
- •Food allergies.
- •Special diets (e.g. vegetarian) or dislikes to any of the foods served during the study.
结局指标
主要结局
Appetite
Energy intake
次要结局
- Energy expenditure and substrate oxidation
- Blood parameters
- Blood pressure and heart rate
研究者
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