Trial of Vitamin C as Add on Therapy for Children With Idiopathic Epilepsy
试验速览
- 阶段
- 2 期
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Seizure severity and frequency, EEG findings
研究概览
简要总结
There are no solid treatment guidelines for idiopathic intractable epilepsy in children. The investigators propose that vitamin C being an antioxidant will improve seizure frequency and EEG in children with idiopathic intractable epilepsy.
详细描述
Is vitamin C; being an antioxidant based on the hypothesis of oxidative stress as a provocation factor for idiopathic epilepsy low in those with idiopathic epilepsy, and is it lower in those with refractory than those with newly diagnosed? Will vitamin C supplementation for 1 month be efficient to raise the vitamin C level and will it improve seizures and EEG findings in those with idiopathic epilepsy?
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 2 Years 至 16 Years（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Normal neuroimaging
排除标准
- •Developmental delay.
- •Suspected metabolic problems.
结局指标
主要结局
Seizure severity and frequency, EEG findings
时间窗: up to 30 days
Seizure severity based on the Chalfont seizre severity scale and daily seizure frequency will be measured before and 30 days after vitamin C supplementation in children with intractable idiopathic epilepsy
次要结局
- vitamin C level in children with epilepsy(6 months)
研究者
Shaymaa Maher Deifalla
Lecturer of Pediatrics, Faculty of Medicine
Ain Shams University