NCT03574064已完成不适用
Investigation of GLP-2 Mechanism of Action
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- N-terminal propeptide of type 1 procollagen (P1NP). At all time points and AUC(0-240 min).
研究概览
简要总结
We will investigate effects of gut hormones on bone remodeling.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 50 Years 至 80 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Women Age above 50 years Postmenopausal Caucasian BMI 18.5 to 28.0 kg/m2.
排除标准
- •Smoking Medication believed to influence study outcome Weight change more than 3 kg whitin the last 3 months Overweight surgery Intestinal surgery Hgb<7,0 mmol/L Decreased renal function
研究组 & 干预措施
GLP-2
Experimental
Glucagon-Like Peptide-2 (GLP-2)
干预措施: Glucagon-Like Peptide-2 (GLP-2) (Other)
GIP
Experimental
Glucose-dependent Insulinotropic polypeptide (GIP)
干预措施: Glucose-dependent insulinotropic polypeptide (GIP) (Other)
GLP-2+GIP
Experimental
GLP-2+GIP
干预措施: GLP-2+GIP (Other)
Placebo
Placebo Comparator
Placebo
干预措施: Placebo (Other)
结局指标
主要结局
N-terminal propeptide of type 1 procollagen (P1NP). At all time points and AUC(0-240 min).
时间窗: -10 minutes to 600 minutes
P1NP is a marker of bone formation. Measured in serum.
C-terminal telopeptide (CTX). At all time points and AUC(0-240 min).
时间窗: -10 minutes to 600 minutes
CTX is a marker of bone resorption. Measured in serum.
次要结局
- PP(-10 minutes to 600 minutes)
- Calcium(-10 minutes to 600 minutes)
- Insulin(-10 minutes to 600 minutes)
- Glukagon-like peptide-2 (GLP-2)(-10 minutes to 600 minutes)
- C-peptide(-10 minutes to 600 minutes)
- PTH(-10 minutes to 600 minutes)
- Sclerostin(-10 minutes to 600 minutes)
- Glucose(-10 minutes to 600 minutes)
- Glucose-dependent insulinotropic polypeptide (GIP)(-10 minutes to 600 minutes)
- Glukagon-like peptide-1 (GLP-1)(-10 minutes to 600 minutes)
- Glucagon(-10 minutes to 600 minutes)
研究者
Kirsa Skov-Jeppesen
Principal Investigator
University of Copenhagen
研究点 (1)
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