临床试验/NCT03573934

NCT03573934已完成不适用

Investigation of GLP-2 Mechanism of Action (KS-2)

University of Copenhagen2 个研究点分布在 1 个国家目标入组 10 人开始时间: 2017年9月15日最近更新: 2020年1月18日

适应症

试验速览

阶段: 不适用
状态: 已完成
发起方: University of Copenhagen
入组人数: 10
试验地点: 2
主要终点: Bone resorption

研究概览研究设计入排标准结局指标研究者研究点记录与标识符相似试验

研究概览

简要总结

Effects of GLP-2 and GIP on bone remodeling in healthy young men.

详细描述

We will investigate acute effects of GLP-2 and GIP on bone remodeling in healthy young men.

研究设计

研究类型: Interventional
分配方式: Randomized
干预模型: Crossover
主要目的: Basic Science
盲法: Single (Participant)

入排标准

年龄范围: 20 Years 至 40 Years（Adult）
性别: Male
接受健康志愿者: 是

入选标准

•Age between 20 and 40 years old Caucasian Healthy BMI between 18.5 and 24.9 kg/m2.

排除标准

•Chronic disease Smoking Medication Weight change more than 3 kg whitin the last 3 months Overweight surgery Intestinal surgery Hgb<8,0 mmol/L Decreased renal function.

结局指标

主要结局

Bone resorption

时间窗: From -10 minutes to 240 minutes.

C-terminal telopeptide (CTX) is a marker of bone resorption. Measured in serum.

Bone formation

时间窗: From -10 minutes to 240 minutes.

P1NP is a marker of bone formation. Measured in serum.

次要结局

Calcium(From -10 minutes to 240 minutes.)
GIP(From -10 minutes to 240 minutes.)
Glucose(From -10 minutes to 240 minutes.)
C-peptide(From -10 minutes to 240 minutes.)
Parathyroid hormone(From -10 minutes to 240 minutes.)
GLP-2(From -10 minutes to 240 minutes.)
Insulin(From -10 minutes to 240 minutes.)
Sclerostin(From -10 minutes to 240 minutes.)

研究者

发起方

University of Copenhagen

申办方类型

Other

责任方

Principal Investigator

主要研究者

Kirsa Skov-Jeppesen

Principal Investigator.

University of Copenhagen

研究点 (2)

Loading locations...

相似试验

招募中

不适用

Gut Peptides and Bone Remodeling in Individuals With Spinal Cord InjurySpinal Cord Injuries

NCT05181150University of Copenhagen20

已完成

不适用

Effects of Gut Peptides on Bone RemodelingHealthy

NCT03574064University of Copenhagen10

已完成

不适用

Effects of Gut Peptides on Bone Remodeling. KS-4-Diabetes-19Type 2 Diabetes Mellitus

NCT03867656University of Copenhagen10

已完成

不适用

Relationships Between GLP-2 and Markers of Bone Turnover Following FeedingObesity

NCT01531907Sheffield Teaching Hospitals NHS Foundation Trust19

进行中（未招募）

不适用

GLP-2 and Bone Resorption. A double-blind, randomized, placebo-controlled, dose ranging, safety, tolerability and pharmacokinetic/dynamic efficacy study with multiple subcutaneous injections of GLP-2 in postmenopausal female volunteers.120 Days of Treatment - GLP-2 and Bone Resorptio

EUCTR2005-003076-37-DKSanos Bioscience A/S160