Gut Hormones and Bone Remodeling in Humans (KS-2)
Not Applicable
Completed
- Conditions
- Healthy
- Registration Number
- NCT03573934
- Lead Sponsor
- University of Copenhagen
- Brief Summary
Effects of GLP-2 and GIP on bone remodeling in healthy young men.
- Detailed Description
We will investigate acute effects of GLP-2 and GIP on bone remodeling in healthy young men.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 10
Inclusion Criteria
Age between 20 and 40 years old Caucasian Healthy BMI between 18.5 and 24.9 kg/m2.
Exclusion Criteria
Chronic disease Smoking Medication Weight change more than 3 kg whitin the last 3 months Overweight surgery Intestinal surgery Hgb<8,0 mmol/L Decreased renal function.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Bone resorption From -10 minutes to 240 minutes. C-terminal telopeptide (CTX) is a marker of bone resorption. Measured in serum.
Bone formation From -10 minutes to 240 minutes. P1NP is a marker of bone formation. Measured in serum.
- Secondary Outcome Measures
Name Time Method Calcium From -10 minutes to 240 minutes. Measured in serum.
GIP From -10 minutes to 240 minutes. Intact and total GIP.
Glucose From -10 minutes to 240 minutes. Measured in serum.
C-peptide From -10 minutes to 240 minutes. Measured in serum.
Parathyroid hormone From -10 minutes to 240 minutes. PTH is a bone marker
Insulin From -10 minutes to 240 minutes. Measured in serum.
Sclerostin From -10 minutes to 240 minutes. Bone marker.
GLP-2 From -10 minutes to 240 minutes. Intact GLP-2
Trial Locations
- Locations (1)
Hvidovre University Hospital
🇩🇰Hvidovre, Denmark
Hvidovre University Hospital🇩🇰Hvidovre, Denmark