NCT03867656已完成不适用
Effects of Gut Peptides on Bone Remodeling. KS-4-Diabetes-19
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- CTX
研究概览
简要总结
Both GLP-2 and GIP reduce the bone resorption (measured as CTX) in healthy persons. In this study, we will investigate wether GLP-2 and GIP is reducing CTX in persons with type 2 diabetes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 25 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Age 25 to 70 years old.
- •Type 2 diabetes.
- •In Metformin or sulfonylureas
排除标准
- •Treatment with other antidiabetics
- •Osteopososis or gastrointestinal disease
- •Long term steroid treatment
- •Weight change more than 3 kg within the last 3 months.
- •Overweight or intestinal surgery
结局指标
主要结局
CTX
时间窗: -10 minutes to 240 minutes
Bone resorption measured as collagen type 1 C-terminal telopeptide (CTX) in serum.
P1NP
时间窗: -10 minutes to 240 minutes
Bone formation measured as procollagen type 1 N-terminal propeptide (P1NP) in serum.
次要结局
- PTH(-10 minutes to 240 minutes)
- Sclerostin(-10 min to 240 min.)
- C-peptide(-10 minutes to 240 minutes)
- Glucose(-10 minutes to 240 minutes)
- Insulin(-10 minutes to 240 minutes)
- GIP(-10 minutes to 240 minutes)
- GLP-2(-10 minutes to 240 minutes)
- Glucagon(-10 minutes to 240 minutes)
- Blood pressure(-10 minutes to 240 minutes)
- Heart rate(-10 minutes to 240 minutes)
研究者
Kirsa Skov-Jeppesen
Principal Investigator
University of Copenhagen
研究点 (2)
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