NCT05181150招募中不适用
Gut Peptides and Bone Remodeling in Individuals With Spinal Cord Injury
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- CTX
研究概览
简要总结
Both GLP-2 and GIP reduce bone resorption (measured as CTX) in healthy persons. In this study, we will investigate whether GLP-2 and GIP is reducing CTX in individuals with spinal cord injury.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •Treatment with antidiabetics
- •Treatment with anti-resorptive agents
- •Gastrointestinal disease
- •Long term steroid treatment
- •Weight change more than 3 kg within the last 3 months.
- •Overweight or intestinal surgery
结局指标
主要结局
CTX
时间窗: -10 to 240 minutes
Bone resorption measured as collagen type 1 C-terminal telopeptide (CTX) in serum.
次要结局
- C-peptide(-10 to 240 minutes)
- GIP(-10 to 240 minutes)
- GLP-2(-10 to 240 minutes)
- Blood pressure(-10 to 240 minutes)
- P1NP(-10 to 240 minutes)
- PTH(-10 to 240 minutes)
- Glucose(-10 to 240 minutes)
- Insulin(-10 to 240 minutes)
- Sclerostin(-10 to 240 minutes)
- Glucagon(-10 to 240 minutes)
- Heart rate(-10 to 240 minutes)
研究者
Kirsa Skov-Jeppesen
Principal investigator
University of Copenhagen
研究点 (2)
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