Effects of Gut Peptides on Bone Remodeling
Not Applicable
Completed
- Conditions
- Healthy
- Registration Number
- NCT03574064
- Lead Sponsor
- University of Copenhagen
- Brief Summary
We will investigate effects of gut hormones on bone remodeling.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Female
- Target Recruitment
- 10
Inclusion Criteria
Women Age above 50 years Postmenopausal Caucasian BMI 18.5 to 28.0 kg/m2.
Exclusion Criteria
Smoking Medication believed to influence study outcome Weight change more than 3 kg whitin the last 3 months Overweight surgery Intestinal surgery Hgb<7,0 mmol/L Decreased renal function
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method N-terminal propeptide of type 1 procollagen (P1NP). At all time points and AUC(0-240 min). -10 minutes to 600 minutes P1NP is a marker of bone formation. Measured in serum.
C-terminal telopeptide (CTX). At all time points and AUC(0-240 min). -10 minutes to 600 minutes CTX is a marker of bone resorption. Measured in serum.
- Secondary Outcome Measures
Name Time Method Calcium -10 minutes to 600 minutes Measured in serum within 5 days.
Glukagon-like peptide-2 (GLP-2) -10 minutes to 600 minutes Intact GLP-2. Measured in plasma.
C-peptide -10 minutes to 600 minutes Measured in serum.
PTH -10 minutes to 600 minutes Bone marker. Measured in serum.
Sclerostin -10 minutes to 600 minutes Bone marker.
PP -10 minutes to 600 minutes Measured in plasma.
Glucose -10 minutes to 600 minutes Measured in serum.
Glucose-dependent insulinotropic polypeptide (GIP) -10 minutes to 600 minutes Total and intact GIP. Measured in plasma.
Glukagon-like peptide-1 (GLP-1) -10 minutes to 600 minutes Measured in plasma.
Glucagon -10 minutes to 600 minutes Measured in plasma.
Insulin -10 minutes to 600 minutes Measured in serum.
Trial Locations
- Locations (1)
Hvidovre University Hospital
🇩🇰Hvidovre, Denmark
Hvidovre University Hospital🇩🇰Hvidovre, Denmark