Prevention of Remifentanil-induced Postoperative Hyperalgesia With Intravenous Ibuprofen
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- cumulative morphine consumption
研究概览
简要总结
Postoperative hyperalgesia has been reported after intraoperative administration of small or high-dose remifentanil. Cyclooxygenase inhibitor exhibit preventive effects on the development of opioid-induced hyperalgesia. The aim of this study is to evaluate the preventive effect of intravenous ibuprofen (Caldolor®) on remifentanil-induced hyperalgesia
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients scheduled for elective pancreaticoduodenectomy
排除标准
- •Patients with chronic pain
- •Patients with psychiatric disease
- •Patients with nonsteroidal antiinflammatory drugs allergy
- •Patients with renail dysfunction
- •History of drug addiction
- •Pregnant patient
- •Inability to use a PCA device
研究组 & 干预措施
high dose remifentanil without ibuprofen
remifentanil target-controlled infusion effect-site concentration 4 ng/ml normal saline before surgical incision
干预措施: high dose remifentanil (Drug)
low dose remifentanil without ibuprofen
remifentanil target-controlled infusion effect-site concentration 1 ng/ml normal saline before surgical incision
干预措施: low dose remifentanil (Drug)
high dose remifentanil with ibuprofen
remifentanil target-controlled infusion effect-site concentration 4 ng/ml Intravenous ibuprofen 800 mg before surgical incision
干预措施: high dose remifentanil (Drug)
high dose remifentanil with ibuprofen
remifentanil target-controlled infusion effect-site concentration 4 ng/ml Intravenous ibuprofen 800 mg before surgical incision
干预措施: Ibuprofen (Drug)
low dose remifentanil with ibuprofen
remifentanil target-controlled infusion effect-site concentration 1 ng/ml Intravenous ibuprofen 800 mg before surgical incision
干预措施: Ibuprofen (Drug)
low dose remifentanil with ibuprofen
remifentanil target-controlled infusion effect-site concentration 1 ng/ml Intravenous ibuprofen 800 mg before surgical incision
干预措施: low dose remifentanil (Drug)
结局指标
主要结局
cumulative morphine consumption
时间窗: postoperative 48 hours
cumulative patient-controlled analgesia (PCA) morphine consumption
次要结局
- Pain score(postoperative 1, 3, 6,12, 24, 48 hours Pain score)