Effects of Postural Adjustment on Hemodynamics in Patients Undergoing Prone Spine Surgery Under General Anesthesia
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Changes in the level of Cardiac output
研究概览
简要总结
The prone position is a special position often used for spinal surgery. As a special position of general anesthesia, after induction of general anesthesia, severe hemodynamic fluctuations often occur when the supine position is changed to the prone position, which seriously affects the patient's circulatory and respiratory functions.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Prone spine surgery after general anesthesia is planned.
- •Age 18~85 years old.
- •ASA grade I or II.
- •BMI18.3-30kg/m2
排除标准
- •Unstable angina or myocardial infarction, coronary heart disease, congestive heart failure, structural heart disease, arrhythmia within 6 months;
- •Increased intracranial pressure and central nervous system injury or disease;
- •Severe hypertension
- •Patients with other diseases affecting their own circulatory system.
- •Have or have a history of severe mental disorders;
- •Bleeding volume >600ml or intraoperative blood transfusion treatment.
- •Severe liver and kidney insufficiency
结局指标
主要结局
Changes in the level of Cardiac output
时间窗: Preoperatively,5 minute after anesthesia induction,Immediately before the prone position, Immediately after the prone position,1 minute after prone position, 3 minute after prone position,10 minute after prone position,Half an hour after prone position
Cardiac output
Change in Blood pressure
时间窗: Preoperatively,5 minute after anesthesia induction,Immediately before the prone position, Immediately after the prone position,1 minute after prone position, 3 minute after prone position,10 minute after prone position,Half an hour after prone position
Hemodynamics
次要结局
- Intra-abdominal pressure level(Preoperatively,5 minute after anesthesia induction,Immediately before the prone position, Immediately after the prone position,1 minute after prone position, 3 minute after prone position,10 minute after prone position,Half an hour after prone position)
- Vasoactive drugs(Intraoperatively)
研究者
Zhuan Zhang
Principal Investigator
Yangzhou University