Hemodynamic Changes Due to Prone Position in Healthy Volunteers
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Hemodynamics Instability
- Sponsor
- University Hospital Hradec Kralove
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Change in Cardiac Index
- Status
- Completed
- Last Updated
- 3 years ago
Overview
Brief Summary
Perioperative prone position may be associated with hemodynamic instability. The causes of instability have not yet been precisely elucidated. The aim of this study is to demonstrate physiological changes during prone positioning in healthy volunteers .
Detailed Description
The prone position could decrease the cardiac index (CI), mainly due to reduction in stroke volume, with little changes in heart rate. Mean arterial pressure (MAP) could be maintained by increased systemic vascular resistance (SVR) in the majority of patients. The aim of this study is to describe hemodynamic changes in two different surgical prone positions in 10 healthy non-anesthetized volunteers (flat position and using a support system allowing a free abdomen) by non-invasive measurement of hemodynamics (ClearSight, Edwards) and indirectly evaluated intra-abdominal pressure using ultrasound. The ClearSight system provides advanced hemodynamic parameters (cardiac index CI, stroke volume SV, stroke volume variation SVV, systemic vascular resistance SVR, mean arterial pressure MAP) from a finger cuff.
Investigators
Dostalova Vlasta, MD, PhD
Principal investigator
University Hospital Hradec Kralove
Eligibility Criteria
Inclusion Criteria
- •age \>18 years,
- •American Society of Anesthesiologists (ASA) Physical Status Classification I
- •agreement with study participation
Exclusion Criteria
- •disagreement with study participation,
- •BMI over 40
- •pregnancy
Outcomes
Primary Outcomes
Change in Cardiac Index
Time Frame: 5 minutes
after changing supine to prone position
Secondary Outcomes
- Changes in vena jugularis diameter(5 minutes)
- Changes in vena cava diameter(5 minutes)
- Changes in vena saphena diameter(5 minutes)
- Changes in vena cephalica diameter(5 minutes)