Hemodynamic Changes Due to Prone Position in Healthy Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Change in Cardiac Index
研究概览
简要总结
Perioperative prone position may be associated with hemodynamic instability. The causes of instability have not yet been precisely elucidated. The aim of this study is to demonstrate physiological changes during prone positioning in healthy volunteers .
详细描述
The prone position could decrease the cardiac index (CI), mainly due to reduction in stroke volume, with little changes in heart rate. Mean arterial pressure (MAP) could be maintained by increased systemic vascular resistance (SVR) in the majority of patients.
The aim of this study is to describe hemodynamic changes in two different surgical prone positions in 10 healthy non-anesthetized volunteers (flat position and using a support system allowing a free abdomen) by non-invasive measurement of hemodynamics (ClearSight, Edwards) and indirectly evaluated intra-abdominal pressure using ultrasound. The ClearSight system provides advanced hemodynamic parameters (cardiac index CI, stroke volume SV, stroke volume variation SVV, systemic vascular resistance SVR, mean arterial pressure MAP) from a finger cuff.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •age >18 years,
- •American Society of Anesthesiologists (ASA) Physical Status Classification I
- •agreement with study participation
排除标准
- •disagreement with study participation,
- •BMI over 40
- •pregnancy
结局指标
主要结局
Change in Cardiac Index
时间窗: 5 minutes
after changing supine to prone position
次要结局
- Changes in vena jugularis diameter(5 minutes)
- Changes in vena cava diameter(5 minutes)
- Changes in vena saphena diameter(5 minutes)
- Changes in vena cephalica diameter(5 minutes)
研究者
Dostalova Vlasta, MD, PhD
Principal investigator
University Hospital Hradec Kralove