The Effects of Altering Physical Activity on Endothelial Function, Glycemic Control, and the Blood Flow Response to an Oral Glucose Tolerance Test.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 1
- 主要终点
- Effects of Physical Inactivity on Post Prandial Blood Flow
研究概览
简要总结
The effects of physical inactivity on variations in blood glucose and vascular health are not fully understood. The purpose of this study is to determine if an acute transition from physical activity to inactivity alters vascular health. Specifically, the investigators wish to examine in healthy, lean physically active individuals (obtaining greater than 10,000 steps/day) if decreasing physical activity (obtaining less than 5,000 steps/day) will alter blood flow following a meal a marker of vascular health. Furthermore, the investigators wish to examine if a one day return to physical activity (obtaining >10,000 steps/day) can restore the detrimental effects on blood flow following a meal.
详细描述
Herein, we tested the hypothesis that an acute reduction in daily activity (from >10,000 to <5,000 steps/day) for 5 days in healthy individuals reduced meal-stimulated blood flow and if a 1 day return to activity improved this outcomes.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 35 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI: less than 30 kg/m2
- •Physically active: exercise greater than 60mins per week
排除标准
- •type 2 diabetes
- •Underlying conditions that limit ability to exercise safely
- •Recent weight gain or loss(> 5% of body weight in 3 months)
- •Recent (< 3 mo) changes in medication use or dose
- •Pregnancy
研究组 & 干预措施
Exercise
5 days of inactivity followed by a 1 day return to physical activity
干预措施: Exercise (Behavioral)
结局指标
主要结局
Effects of Physical Inactivity on Post Prandial Blood Flow
时间窗: 10 days
There was a pre-measurement period of 3 days, then 5 days of inactivity, followed by 1.5-2 days of return to activity. A 10 day time frame overall. Blood flow measured by Doppler ultrasound during an oral glucose tolerance test before and after 5 days of inactivity.
次要结局
未报告次要终点