Comparison of Clonidine vs Dexmedetomidine vs Dexamethasone as an adjuvant to local anesthetic for Femoral nerve block in patient for elective anterior cruciate ligament reconstruction surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 90
- 试验地点
- 1
- 主要终点
- VAS score less than 3 (Duration of Analgesia)
研究概览
简要总结
A prospectiverandomized double blind controlled trial including 90 ASA I & II patientsbetween age 18 – 65 yrs for elective arthroscopic anterior cruciate ligamentreconstruction surgery divided into 3 groups Group A Clonidine plusBupivacaine, Group B Dexmedetomidine plus Bupivacaine and Group C Dexamethasoneand Bupivacaine. The study compares the effects of clonidine,dexmedetomidine and dexamethasone as an adjuvant to bupivacaine in arthroscopicanterior cruciate ligament reconstruction surgeries in postoperativeperiod for 24 hrs after ultrasound and peripheral nerve stimulation guidedfemoral nerve block and thus concluding which drug combination produces betteranalgesia with minimal haemodynamic alterations.
Findingsummary: Addition of Dexamethasone to local anesthetic drugs in femoralblock significantly prolongs the onset and duration of analgesia, sensory andmotor block as compared to clonidine and dexmedetomidine in patients undergoingACL reconstruction surgeries. Dexamethasone as an additive provides: Betterpain relief, prolongation of post operative analgesia and, decrease consumptionof systemic analgesics in post operative period with manageable hemodynamicalterations. It is a remarkably, safe and cost effective method of providingpostoperative analgesia. US-guided brachial plexus block technique has severaladvantages including faster onset and greater block success.
研究设计
- 研究类型
- Interventional
- 分配方式
- Computer generated randomization
- 盲法
- Participant, Investigator and Outcome Assessor Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •All patients of ASA physical status I and II 2) Patient posted for elective surgical procedure.
排除标准
- •Patient less than 18 year and more than 65 year 2) Pregnant and lactating women 3) Hemodynamically compromised patient 4) Non consenting patient/relatives refusal for procedure 5) Surgery on emergency patients with associated uncontrolled systemic disease 6) Patients in ASA physical status III and IV 7) Allergic to Medication 8) Bleeding diathesis.
结局指标
主要结局
VAS score less than 3 (Duration of Analgesia)
时间窗: 48 Hours
次要结局
- Onset and Duration of Sensory blockade, Rescue Analgesia(48 Hours)